Tnfsf4 - tumor necrosis factor (ligand) superfamily, member 4 Gene

Also Known as Ath1; gp34; Ath-1; Ox40l; TXGP1; CD134L; OX-40L; Tnlg2b; Txgp1l

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22164

Summary

Enables tumor necrosis factor receptor binding activity. Involved in several processes, including T cell activation; regulation of gene expression; and regulation of lymphocyte activation. Acts upstream of or within Cholesterol metabolic process; inflammatory response; and negative regulation of cytokine production. Predicted to be located in cell surface. Predicted to be active in extracellular space. Is expressed in sensory organ and skeleton. Used to study primary pulmonary hypertension and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human TNFSF4 (TNF Superfamily member 4). [provided by Alliance of Genome Resources, Apr 2022]

Tnfsf4 Products (1)

mRNA Protein Name
NM_009452.2 NP_033478.1 tumor necrosis factor ligand superfamily member 4
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 4

  • OX40 ligand

  • atherosclerosis 1

  • tax-transcriptionally activated glycoprotein 1 ligand

  • tumor necrosis factor ligand 2b

Tnfsf4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Tnfsf4 P43488 TNFSF4 Homo sapiens P23510
X-Ray Diffraction
16905106
Cross
Tnfsf4 P43488 TNFSF4 Homo sapiens P23510
GMS
16905106
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Tnfsf4 Proteins

Cat. No. Product Name Accession Purity
HY-P72497 OX40 Ligand/TNFSF4 Protein, Mouse (HEK293, His) P43488 (S51-L198) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77459 OX40 Ligand/TNFSF4 Protein, Mouse (HEK293, Fc) P43488 (Q49-L198) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77460 OX40 Ligand/TNFSF4 Protein, Mouse (HEK293, rFc) P43488 (Q49-L198) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700225AF Animal-Free OX40 Ligand/TNFSF4 Protein, Mouse (His) P43488 (Q49-L198) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14828 TNFSF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17931 Tnfsf4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24401 Tnfsf4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992122 Olevaprubart 99.43% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfsf4 NCBI NCBI:7292