1. Anti-infection
    Membrane Transporter/Ion Channel
  2. Bacterial
    Fungal
    Na+/K+ ATPase
  3. Bafilomycin C1

Bafilomycin C1 

Cat. No.: HY-130173
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Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H+-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi. Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC).

For research use only. We do not sell to patients.

Bafilomycin C1 Chemical Structure

Bafilomycin C1 Chemical Structure

CAS No. : 88979-61-7

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Description

Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H+-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi[2]. Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC)[2].

In Vitro

Bafilomycin C1 (0.33-10 μM; 6 days) inhibits the growth and proliferation of SMMC7721 and HepG2 cells in a timeand dose-dependent manner[2].
Bafilomycin C1 (0.33-3.3 μM; 24 hours) decreases cyclin D3, cyclin E1, CDK2, CDK4, and CDK6 expression in both mRNA and protein expression in SMMC7721 cells[2].
Bafilomycin C1 (3.3-10 μM; 24 hours) causes morphological alterations and increases the population of apoptotic cells by Hoechst 33258 (HY-15558) staining compared to vehicle[2].

Cell Viability Assay[2]

Cell Line: SMMC7721 cell and HepG2 cell
Concentration: 0.33 μM, 1.1 μM, and 3.3 μM for SMMC7721
1.1 μM, 3.3 μM, and 10.0 μM for HepG2
Incubation Time: 6 days
Result: Retarded the cell growth.

Western Blot Analysis[2]

Cell Line: SMMC7721 cells
Concentration: 3.3 μM
Incubation Time: 24 hours
Result: Decreaed cyclin D3/E1,CDK2/4/6 protein expression and increased p21.

Apoptosis Analysis[2]

Cell Line: SMMC7721 and HepG2 cells
Concentration: 3.3 μM; 10 μM
Incubation Time: 24 hours
Result: Induced apoptosis in SMMC7721 and HepG2 cells.
In Vivo

Bafilomycin C1 (subcutaneous injection; 0.2 mg/kg; 20 days) retards the tumor growth without apparent adverse reactions or side effects in nude mice model[1].

Animal Model: BALB/c nude mice (weighing 18-20 g) subcutaneous injected by SMMC7721 cell suspension (5×106 cells/100 μL)[2]
Dosage: 0.2 mg/kg
Administration: Subcutaneous injection; 20 days
Result: Suppressed tumor growth of SMMC7721 tumor xenografts.
Molecular Weight

720.89

Formula

C₃₉H₆₀O₁₂

CAS No.

88979-61-7

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vivo:
  • 1.

    Bafilomycin C1 (0.2 mg/kg body weight, dissolved in 60% 1,2-propanediol)[2]

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Keywords:

Bafilomycin C1Bafilomycin C 1Bafilomycin C-1BacterialFungalNa+/K+ ATPaseSodium potassium pumpprokaryoticeukaryoticSMMC7721HepatocellularcarcinomaHCChepaticchemotherapyInhibitorinhibitorinhibit

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Bafilomycin C1
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