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Cat. No.: HY-115902

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FGFR4-IN-7

FGFR4-IN-7 (Compound C3) is a covalent reversible FGFR4 inhibitor with an IC₅₀ value of 0.42 μM. FGFR4-IN-7 induces apoptosis via the FGFR4 signaling pathway blockage. FGFR4-IN-7 can be used for the research of hepatocellular carcinoma (HCC).

For research use only. We do not sell to patients.

CAS No.: 2765046-07-7
Formula: C₂₆H₂₅Cl₂N₅O₃
Molecular Weight:526.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

FGFR4-IN-7 Chemical Structure

CAS No.: 2765046-07-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Hep 3B2	IC₅₀	9 μM Compound: 4	Antiproliferative activity against FGF19/FGFR4 dependent human Hep3B cells assessed as reduction in cell viability Antiproliferative activity against FGF19/FGFR4 dependent human Hep3B cells assessed as reduction in cell viability	[PMID: 37976704]
Huh-7	IC₅₀	9.2 μM Compound: 4	Antiproliferative activity against FGF19/FGFR4 dependent human Huh-7 cells assessed as reduction in cell viability Antiproliferative activity against FGF19/FGFR4 dependent human Huh-7 cells assessed as reduction in cell viability	[PMID: 37976704]

Chemical Information

CAS No. 2765046-07-7
Molecular Weight 526.41
Formula C₂₆H₂₅Cl₂N₅O₃
SMILES

COC1=CC(OC)=C(C(C2=CC3=CN=C(N=C3C=C2)NCCCNC(/C(C#N)=C/C4CC4)=O)=C1Cl)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wenwen Nie, et al. Design, synthesis, and biological evaluation of quinazoline derivatives with covalent reversible warheads as potential FGFR4 inhibitors. Bioorg Chem. 2022 Apr;121:105673. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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