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Cat. No.: HY-161825

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Tubulin polymerization-IN-66

Tubulin polymerization-IN-66 (Compound 13) inhibits colony formation and tubulin polymerization. Tubulin polymerization-IN-66 induces apoptosis. Tubulin polymerization-IN-66 inhibits cell viability of A549, A2780, SKOV3, HCC827 cells, with IC₅₀s of 0.84, 0.38, 0.31, 0.34 nM respectively. Tubulin polymerization-IN-66 is also active against the Paclitaxel (HY-B0015)-resistant cancer cell line A2780/T and its parental cell line A2780.

For research use only. We do not sell to patients.

Formula: C₁₅H₁₁ClN₄O₂S
Molecular Weight:346.79

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Tubulin polymerization-IN-66 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.38 nM Compound: 13	Antiproliferative activity against human A2780 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A2780 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]
A549	IC₅₀	0.84 nM Compound: 13	Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]
HCC827	IC₅₀	0.34 nM Compound: 13	Antiproliferative activity against human HCC827 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human HCC827 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]
SK-OV-3	IC₅₀	0.31 nM Compound: 13	Antiproliferative activity against human SK-OV-3 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human SK-OV-3 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]

Chemical Information

Molecular Weight 346.79
Formula C₁₅H₁₁ClN₄O₂S
SMILES

ClC1=NC2=C(SC=C2)C(N3C4=CC=C(OC)C=C4NC(C3)=O)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu C, et al. Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy. Eur J Med Chem. 2024 Jul 4;276:116649. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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