PROTAC EGFR degrader 8
Based on 1 Customer Validation
PROTAC EGFR degrader 8 (T-184) is a PROTAC degrader that targets EGFR for degradation by recruiting cereblon. It induces EGFR protein degradation with a DC50 of 10.18 nM. The IC50 values of PROTAC EGFR degrader 8 for inhibiting the growth of H1975, PC-9 and HCC827 cells are 7.72, 121.9 and 14.21 nM, respectively. PROTAC EGFR degrader 8 inhibits the proliferation of EGFR-mutant non-small cell lung cancer cells and can be used in studies related to non-small cell lung cancer.
(Pink: EGFR Target protein ligand; Blue: Cereblon ligand (HY-150799); Black: linker).
For research use only. We do not sell to patients.
- Purity: 98.90%
- CAS No.: 2925923-46-0
- Formula: C40H46ClN11O5
- Molecular Weight:796.32
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
PROTAC EGFR degrader 8 (T-184) inhibits the viability of H1975, PC-9 and HCC827 non-small cell lung cancer cell lines, with IC50 values of 7.72 nM, 121.9 nM and 14.21 nM, respectively[1].
PROTAC EGFR degrader 8 induces EGFR protein degradation in HCC827 non-small cell lung cancer cells, with a DC50 of 10.18 nM and a Dmax of 70.8%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2925923-46-0
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Appearance Solid
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Molecular Weight 796.32
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Formula C40H46ClN11O5
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Color Light brown to brown
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SMILES
O=C(C1=C(NC2=NC(NC3=CC=C(N4CCN(CC4)C(CN5CCN(CC5)C6=CC=C(NC7C(NC(CC7)=O)=O)C=C6)=O)C=C3OC)=NC=C2Cl)C=CC=C1)NC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (125.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2558 mL | 6.2789 mL | 12.5578 mL | 31.3944 mL |
| 5 mM | 0.2512 mL | 1.2558 mL | 2.5116 mL | 6.2789 mL | |
| 10 mM | 0.1256 mL | 0.6279 mL | 1.2558 mL | 3.1394 mL | |
| 15 mM | 0.0837 mL | 0.4186 mL | 0.8372 mL | 2.0930 mL | |
| 20 mM | 0.0628 mL | 0.3139 mL | 0.6279 mL | 1.5697 mL | |
| 25 mM | 0.0502 mL | 0.2512 mL | 0.5023 mL | 1.2558 mL | |
| 30 mM | 0.0419 mL | 0.2093 mL | 0.4186 mL | 1.0465 mL | |
| 40 mM | 0.0314 mL | 0.1570 mL | 0.3139 mL | 0.7849 mL | |
| 50 mM | 0.0251 mL | 0.1256 mL | 0.2512 mL | 0.6279 mL | |
| 60 mM | 0.0209 mL | 0.1046 mL | 0.2093 mL | 0.5232 mL | |
| 80 mM | 0.0157 mL | 0.0785 mL | 0.1570 mL | 0.3924 mL | |
| 100 mM | 0.0126 mL | 0.0628 mL | 0.1256 mL | 0.3139 mL |
PROTAC EGFR degrader 8 Related Classifications
HY-153901 Related Classifications
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