2925923-46-0
Chemical Structure
PROTAC EGFR degrader 8
- CAS No.: 2925923-46-0
- Formula:C40H46ClN11O5
- Molecular Weight:796.32
InChIKey: YDHBIZKMLPNNQN-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC2=NC(NC3=CC=C(N4CCN(CC4)C(CN5CCN(CC5)C6=CC=C(NC7C(NC(CC7)=O)=O)C=C6)=O)C=C3OC)=NC=C2Cl)C=CC=C1)NC
Biological Activity: PROTAC EGFR degrader 8 (T-184) is a PROTAC degrader that targets EGFR for degradation by recruiting cereblon. It induces EGFR protein degradation with a DC50 of 10.18 nM. The IC50 values of PROTAC EGFR degrader 8 for inhibiting the growth of H1975, PC-9 and HCC827 cells are 7.72, 121.9 and 14.21 nM, respectively. PROTAC EGFR degrader 8 inhibits the proliferation of EGFR-mutant non-small cell lung cancer cells and can be used in studies related to non-small cell lung cancer[1].
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PROTAC EGFR degrader 8 | 98.90% | PROTAC EGFR degrader 8 (T-184) is a PROTAC degrader that targets EGFR for degradation by recruiting cereblon. It induces EGFR protein degradation with a DC50 of 10.18 nM. The IC50 values of PROTAC EGFR degrader 8 for inhibiting the growth of H1975, PC-9 and HCC827 cells are 7.72, 121.9 and 14.21 nM, respectively. PROTAC EGFR degrader 8 inhibits the proliferation of EGFR-mutant non-small cell lung cancer cells and can be used in studies related to non-small cell lung cancer. | ||||||||||||||||||||
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Keywords
