1. Protein Tyrosine Kinase/RTK
    PROTAC
  2. FAK
    PROTACs
  3. FAK PROTAC B5

FAK PROTAC B5 

Cat. No.: HY-143458
Handling Instructions

FAK PROTAC B5 (Compound B5) is a FAK PROTAC degrader with an IC50 value of 14.9 nM. FAK PROTAC B5 presents strong FAK degradation activity, antiproliferative activity, outstanding plasma stability and moderate membrane permeability. FAK PROTAC B5 inhibits cell migration and invasion.

For research use only. We do not sell to patients.

FAK PROTAC B5 Chemical Structure

FAK PROTAC B5 Chemical Structure

CAS No. : 2471525-44-5

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Description

FAK PROTAC B5 (Compound B5) is a FAK PROTAC degrader with an IC50 value of 14.9 nM. FAK PROTAC B5 presents strong FAK degradation activity, antiproliferative activity, outstanding plasma stability and moderate membrane permeability. FAK PROTAC B5 inhibits cell migration and invasion[1].

IC50 & Target

IC50: 14.9 nM (FAK)[1]

In Vitro

FAK PROTAC B5 (Compound B5) displays strong antiproliferative activity (IC50 = 0.14 ± 0.01 μM) against A549 cells[1].
FAK PROTAC B5 displays excellent FAK degradation activity (86.4% at 10 nM) and the degradation is realized through proteasome degradation pathway[1].
FAK PROTAC B5 (0-1.8 μM, 72 h) has the significant ability to inhibit the migration of A549 cells[1].
FAK PROTAC B5 (0-1.8 μM, 72 h) inhibits the invasion of A549 cells in a concentration-dependent manner[1].
FAK PROTAC B5 exhibits a moderate membrane permeability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: A549
Concentration: 0.01 μM, 0.1 μM, 1 μM
Incubation Time: 8 h
Result: Reduced the level of FAK protein in a dose-dependent manner. Displayed excellent FAK degradation activity (86.4% at 10 nM).

Cell Invasion Assay[1]

Cell Line: A549
Concentration: 0.20, 0.60 and 1.80 μM
Incubation Time: 72 h
Result: Significantly reduced the number of A549 cells in a concentration-dependent manner.
In Vivo

FAK PROTAC B5 (Compound B5) possesses favorable plasma stability with the half-life value greater than 289.1 min[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

823.30

Formula

C41H43ClN10O7

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
FAK PROTAC B5
Cat. No.:
HY-143458
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