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Cat. No.: HY-169481

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AP-1

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Based on 1 Customer Validation

AP-1 is a PROTAC targeting anaplastic lymphoma kinase (ALK).
(Pink: Anaplastic lymphoma kinase (ALK) ligand (HY-169482); Blue: Cereblon ligand (HY-10984); Black: linker).

For research use only. We do not sell to patients.

Purity: 97.8%
CAS No.: 3027918-96-0
Formula: C₃₉H₄₀ClN₉O₈S
Molecular Weight:830.31

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

AP-1 Chemical Structure

CAS No.: 3027918-96-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

AP-1 is a PROTAC targeting anaplastic lymphoma kinase (ALK)^[1]. (Pink: Anaplastic lymphoma kinase (ALK) ligand (HY-169482); Blue: Cereblon ligand (HY-10984); Black: linker).

All PROTACs Isoforms :

Chemical Information

CAS No. 3027918-96-0
Appearance Solid
Molecular Weight 830.31
Formula C₃₉H₄₀ClN₉O₈S
Color Yellow to orange
SMILES

O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCC(N4CCN(CC4)C5=CC=C(C(OC)=C5)NC6=NC=C(C(NC7=C(S(=O)(C(C)C)=O)C=CC=C7)=N6)Cl)=O)=CC=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lidong Gong, et al. Discovery of a miniaturized PROTAC with potent activity and high selectivity. Bioorg Chem. 2023 Jul:136:106556. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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AP-1

High-Throughput Bioactive Compound Library

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

AP-1 Related Classifications

HY-169481 Related Classifications