LL-Z1640-4
Based on 1 Customer Validation
LL-Z1640-4 is a potent p38/JNK signaling inhibitor. LL-Z1640-4 significantly diminishes p38 and JNK activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates ROS production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.0%
- No. CAS: 66018-41-5
- Fòrmula: C19H24O7
- Peso molecular:364.39
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
>50 μM
Compound: 2
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Inhibition of NFkappa p65 isolated from nuclear extract of human HeLa cells by ELISA
Inhibition of NFkappa p65 isolated from nuclear extract of human HeLa cells by ELISA
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[PMID: 21513293] |
| HT-29 | IC50 |
>25 μM
Compound: 2
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Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay
Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay
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[PMID: 21513293] |
| MCF7 | IC50 |
>100 μM
Compound: 2
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Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
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[PMID: 21513293] |
| MDA-MB-435 | IC50 |
>25 μM
Compound: 2
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Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTS assay
Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTS assay
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[PMID: 21513293] |
| NCI-H460 | IC50 |
>100 μM
Compound: 2
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Cytotoxicity against human H460 cells after 72 hrs by MTS assay
Cytotoxicity against human H460 cells after 72 hrs by MTS assay
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[PMID: 21513293] |
| SF-268 | IC50 |
>100 μM
Compound: 2
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Cytotoxicity against human SF268 cells after 72 hrs by MTS assay
Cytotoxicity against human SF268 cells after 72 hrs by MTS assay
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[PMID: 21513293] |
LL-Z1640-4 markedly restores the number of cells in migration and invasion decreased by siMLK4, and significantly up-regulates expression of MMP2 and Vimentin[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 66018-41-5
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Appearance Solid
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Peso molecular 364.39
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Fòrmula C19H24O7
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Color White to off-white
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SMILES
O=C1OC(C/C=C/C(C(C(C/C=C/C2=C1C(O)=CC(OC)=C2)O)O)O)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LL-Z1640-4 Related Classifications
HY-120349 Related Classifications
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