2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. ROS-ERS inducer 1

ROS-ERS inducer 1 is a type II ICD (immunogenic cell death) inducer. ROS-ERS inducer 1 is a Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complex derived from 4,5-diarylimidazole. ROS-ERS inducer 1 successfully induces endoplasmic reticulum stress (ERS) accompanied by reactive oxygen species (ROS) generation and finally lead to the release of damage-associated molecular patterns (DAMPs) in HCC cells. ROS-ERS inducer 1 displays much higher anticancer activities than Cisplatin.

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ROS-ERS inducer 1 Chemical Structure

ROS-ERS inducer 1 Chemical Structure

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5 mg USD 400 In-stock
10 mg USD 650 In-stock
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Description

ROS-ERS inducer 1 is a type II ICD (immunogenic cell death) inducer. ROS-ERS inducer 1 is a Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complex derived from 4,5-diarylimidazole. ROS-ERS inducer 1 successfully induces endoplasmic reticulum stress (ERS) accompanied by reactive oxygen species (ROS) generation and finally lead to the release of damage-associated molecular patterns (DAMPs) in HCC cells. ROS-ERS inducer 1 displays much higher anticancer activities than Cisplatin[1].

Molecular Weight

840.35

Formula

C24H23F2I2N3Pt
Appearance

Solid

Color

Light yellow to yellow

SMILES

FC(C=C1)=CC=C1c2c(C3=CC=C(F)C=C3)n(CC)c([Pt]([N]4=CC=CC=C4)(I)I)n2CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 60 mg/mL (71.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1900 mL 5.9499 mL 11.8998 mL
5 mM 0.2380 mL 1.1900 mL 2.3800 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1900 mL 5.9499 mL 11.8998 mL 29.7495 mL
5 mM 0.2380 mL 1.1900 mL 2.3800 mL 5.9499 mL
10 mM 0.1190 mL 0.5950 mL 1.1900 mL 2.9750 mL
15 mM 0.0793 mL 0.3967 mL 0.7933 mL 1.9833 mL
20 mM 0.0595 mL 0.2975 mL 0.5950 mL 1.4875 mL
25 mM 0.0476 mL 0.2380 mL 0.4760 mL 1.1900 mL
30 mM 0.0397 mL 0.1983 mL 0.3967 mL 0.9917 mL
40 mM 0.0297 mL 0.1487 mL 0.2975 mL 0.7437 mL
50 mM 0.0238 mL 0.1190 mL 0.2380 mL 0.5950 mL
60 mM 0.0198 mL 0.0992 mL 0.1983 mL 0.4958 mL
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ROS-ERS inducer 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ROS-ERS inducer 1Reactive Oxygen SpeciesICDERSROSDAMPanticancerCisplatinInhibitorinhibitorinhibit

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