JMJD6-IN-1
Based on 1 publication(s) in Google Scholar
JMJD6-IN-1 is a JMJD6 inhibitor, with an inhibition rate of 82% at 10 μM. JMJD6-IN-1 inhibits MCF-7 and HCC4006 cell proliferation with IC50 values of 19.2 μM and 25.2 μM. JMJD6-IN-1 inhibits JMJD6 demethylase activity. JMJD6-IN-1 can be used for the research of lung adenocarcinoma, prostate cancer, breast cancer, pancreatic cancer, colon cancer, oral squamous cell carcinoma, and glioblastoma.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.51%
- CAS 番号: 899548-78-8
- 分子式: C16H11N3O2
- 分子量:277.28
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 JMJD6-IN-1
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生物活性
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Cell Line
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Type | Value | Description | References |
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| HeLa | IC50 |
2.44 μM
Compound: WL12
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Inhibition of JMJD6 in human HeLa cells assessed as decrease in cell proliferation measured after 72 hrs by CellTiter 96 AQueous one solution cell proliferation assay
Inhibition of JMJD6 in human HeLa cells assessed as decrease in cell proliferation measured after 72 hrs by CellTiter 96 AQueous one solution cell proliferation assay
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[PMID: 31857835] |
JMJD6-IN-1 (Comp 1-3) (10 μM; 30 min) inhibits purified JMJD6 demethylase activity by 82%[1].
JMJD6-IN-1 (0.3-100 μM; 48 h) inhibits the proliferation of MCF7 breast cancer cells and HCC4006 lung adenocarcinoma cells with IC50 values of 14.5 μM and 23.4 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF7 breast cancer cells
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Concentration:0.3, 1, 3, 10, 30, 100 μM
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Incubation Time:48 h
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Result:Inhibited MCF7 breast cancer cell proliferation with an IC50 of 14.5 μM.
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Cell Line:HCC4006 lung adenocarcinoma cells
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Concentration:0.3, 1, 3, 10, 30, 100 μM
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Incubation Time:48 h
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Result:Inhibited HCC4006 lung adenocarcinoma cell proliferation with an IC50 of 23.4 μM.
化学情報
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CAS 番号 899548-78-8
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性状 Solid
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分子量 277.28
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分子式 C16H11N3O2
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Color Light yellow to yellow
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SMILES
O=C1C(C(N2)=NC3=C2C=NC=C3)=CC4=CC(C)=CC=C4O1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Virol
JMJD6-mediated epigenetic silencing of innate immunity promotes pseudorabies virus replication. [Abstract]2026 Apr 29:e0002826. PMID: 42053297
溶剤 & 溶解度
DMF : 10 mg/mL (36.06 mM; Need ultrasonic)
DMSO : 5 mg/mL (18.03 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / DMF | 1 mM | 3.6065 mL | 18.0323 mL | 36.0646 mL | 90.1616 mL |
| 5 mM | 0.7213 mL | 3.6065 mL | 7.2129 mL | 18.0323 mL | |
| 10 mM | 0.3606 mL | 1.8032 mL | 3.6065 mL | 9.0162 mL | |
| 15 mM | 0.2404 mL | 1.2022 mL | 2.4043 mL | 6.0108 mL | |
| DMF | 20 mM | 0.1803 mL | 0.9016 mL | 1.8032 mL | 4.5081 mL |
| 25 mM | 0.1443 mL | 0.7213 mL | 1.4426 mL | 3.6065 mL | |
| 30 mM | 0.1202 mL | 0.6011 mL | 1.2022 mL | 3.0054 mL |
JMJD6-IN-1 関連分類
HY-139434 関連分類
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