1. Alkaloid
  2. Isocorydine

Isocorydine 

Cat. No.: HY-N2591
Handling Instructions

Isocorydine is isolated from Dicranostigma leptopodum (Maxim.) Fedde (DLF). Isocorydine combines with Doxorubicin (DOX) has a promising potential to eradicate hepatocellular carcinoma (HCC).

For research use only. We do not sell to patients.

Isocorydine Chemical Structure

Isocorydine Chemical Structure

CAS No. : 475-67-2

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
20 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Isocorydine is isolated from Dicranostigma leptopodum (Maxim.) Fedde (DLF). Isocorydine combines with Doxorubicin (DOX) has a promising potential to eradicate hepatocellular carcinoma (HCC)[1].

In Vitro

Isocorydine (0-400 ug/ml; 48 hours) show a significant decrease in the IC50 for ICD and DOX, the CI values are 0.605, 0.644, 0.804, and 0.707 respectively for Huh-7, Hep-G2, SNU-449 and SNU-387[1].
Isocorydine (0-400 ug/ml; 48 hours) abrogates DOX-induced upregulation of mesenchymal markers and the downregulation of epithelial markers in human HCC cell lines[1].

Cell Viability Assay[1]

Cell Line: Huh-7, Hep-G2 , SNU-387, SNU-449 cells
Concentration: 0-400 ug/ml
Incubation Time: 24 hours
Result: Had a higher cytotoxicity in HCC cells in comparison to ICD or DOX alone.

Western Blot Analysis[1]

Cell Line: Huh-7, Hep-G2 , SNU-387, SNU-449 cells
Concentration:
Incubation Time: 24 hours
Result: Downregulated protein levels of Claundin-1 and E-cadherin.
In Vivo

Isocorydine (intraperitoneal injection; 0.4 mg/kg; every 2 days for 2 weeks) retards the tumor growth, but the combined treatment of Doxorubicin (DOX) or ICD significantly inhibits tumor growth[1].

Animal Model: Female nude mice[1]
Dosage: 0.4 mg/ml
Administration: Injected intraperitoneally every 2 days for 2 weeks
Result: Combined treatment of isocorydine and DOX showed a promising potential to eradicate HCC.
Molecular Weight

341.40

Formula

C₂₀H₂₃NO₄

CAS No.

475-67-2

SMILES

COC1=C2C3=C(C=C1OC)CCN(C)[[email protected]@]3([H])CC4=CC=C(OC)C(O)=C24

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

IsocorydineOthersInhibitorinhibitorinhibit

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