2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. MC-GGFG-AM-(10Me-11F-Camptothecin)

MC-GGFG-AM-(10Me-11F-Camptothecin) 

Cat. No.: HY-153360 Purity: 98.06%
COA Handling Instructions

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MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells.

For research use only. We do not sell to patients.

MC-GGFG-AM-(10Me-11F-Camptothecin) Chemical Structure

MC-GGFG-AM-(10Me-11F-Camptothecin) Chemical Structure

CAS No. : 2873460-70-7

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1 mg USD 980 In-stock
5 mg USD 2400 In-stock
10 mg USD 3900 In-stock
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Based on 1 publication(s) in Google Scholar

MC-GGFG-AM-(10Me-11F-Camptothecin) Related Antibodies

Top Publications Citing Use of Products

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Topoisomerase Topo I Topo II

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells[1].

IC50 & Target[1]

Topoisomerase I

 

Molecular Weight

1038.04

Formula

C51H56FN9O14
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=C(C)C=C2C(CNC(OCCOCNC(CNC([C@H](CC3=CC=CC=C3)NC(CNC(CNC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)=O)=C5C(C(N6C5)=CC([C@@](O)(CC)C(OC7)=O)=C7C6=O)=NC2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (96.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9634 mL 4.8168 mL 9.6335 mL
5 mM 0.1927 mL 0.9634 mL 1.9267 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9634 mL 4.8168 mL 9.6335 mL 24.0838 mL
5 mM 0.1927 mL 0.9634 mL 1.9267 mL 4.8168 mL
10 mM 0.0963 mL 0.4817 mL 0.9634 mL 2.4084 mL
15 mM 0.0642 mL 0.3211 mL 0.6422 mL 1.6056 mL
20 mM 0.0482 mL 0.2408 mL 0.4817 mL 1.2042 mL
25 mM 0.0385 mL 0.1927 mL 0.3853 mL 0.9634 mL
30 mM 0.0321 mL 0.1606 mL 0.3211 mL 0.8028 mL
40 mM 0.0241 mL 0.1204 mL 0.2408 mL 0.6021 mL
50 mM 0.0193 mL 0.0963 mL 0.1927 mL 0.4817 mL
60 mM 0.0161 mL 0.0803 mL 0.1606 mL 0.4014 mL
80 mM 0.0120 mL 0.0602 mL 0.1204 mL 0.3010 mL
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MC-GGFG-AM-(10Me-11F-Camptothecin) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-GGFG-AM-(10Me-11F-Camptothecin)2873460-70-7Drug-Linker Conjugates for ADCTopoisomeraseInhibitorinhibitorinhibit

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