MC-GGFG-AM-(10Me-11F-Camptothecin)

Name: MC-GGFG-AM-(10Me-11F-Camptothecin)
Brand: MedChemExpress
SKU: HY-153360
Rating: 4.5 (0 reviews)

Cat. No.: HY-153360 Purity: 98.99%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells.

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MC-GGFG-AM-(10Me-11F-Camptothecin) 화학구조

CAS No. : 2873460-70-7

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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•Related Small Molecules:

•Related Proteins:

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

View All Topoisomerase Isoform Specific Products:

View All Isoforms

Topoisomerase Topo I Topo II DNA gyrase

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target^[1]

Topoisomerase I

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

분자량

1038.04

화학식

C₅₁H₅₆FN₉O₁₄

CAS No.

2873460-70-7

Appearance

Solid

Color

White to off-white

SMILES

FC1=C(C)C=C2C(CNC(OCCOCNC(CNC([C@H](CC3=CC=CC=C3)NC(CNC(CNC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)=O)=C5C(C(N6C5)=CC([C@@](O)(CC)C(OC7)=O)=C7C6=O)=NC2=C1

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (96.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9634 mL	4.8168 mL	9.6335 mL
5 mM	0.1927 mL	0.9634 mL	1.9267 mL
10 mM	0.0963 mL	0.4817 mL	0.9634 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.99%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (245 KB) HNMR (299 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

References

[1]. Madera L, et al. ZW251, a novel glypican-3-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload[J]. Cancer Research, 2023, 83(7_Supplement): 2658-2658.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9634 mL	4.8168 mL	9.6335 mL	24.0838 mL
	5 mM	0.1927 mL	0.9634 mL	1.9267 mL	4.8168 mL
	10 mM	0.0963 mL	0.4817 mL	0.9634 mL	2.4084 mL
	15 mM	0.0642 mL	0.3211 mL	0.6422 mL	1.6056 mL
	20 mM	0.0482 mL	0.2408 mL	0.4817 mL	1.2042 mL
	25 mM	0.0385 mL	0.1927 mL	0.3853 mL	0.9634 mL
	30 mM	0.0321 mL	0.1606 mL	0.3211 mL	0.8028 mL
	40 mM	0.0241 mL	0.1204 mL	0.2408 mL	0.6021 mL
	50 mM	0.0193 mL	0.0963 mL	0.1927 mL	0.4817 mL
	60 mM	0.0161 mL	0.0803 mL	0.1606 mL	0.4014 mL
	80 mM	0.0120 mL	0.0602 mL	0.1204 mL	0.3010 mL