MC-GGFG-AM-(10Me-11F-Camptothecin)
Based on 1 Customer Validation
MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells.
For research use only. We do not sell to patients.
- Purity: 98.99%
- CAS No.: 2873460-70-7
- Formula: C51H56FN9O14
- Molecular Weight:1038.04
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Topoisomerase I |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2873460-70-7
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Appearance Solid
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Molecular Weight 1038.04
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Formula C51H56FN9O14
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Color White to off-white
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SMILES
FC1=C(C)C=C2C(CNC(OCCOCNC(CNC([C@H](CC3=CC=CC=C3)NC(CNC(CNC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)=O)=C5C(C(N6C5)=CC([C@@](O)(CC)C(OC7)=O)=C7C6=O)=NC2=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (96.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9634 mL | 4.8168 mL | 9.6335 mL | 24.0838 mL |
| 5 mM | 0.1927 mL | 0.9634 mL | 1.9267 mL | 4.8168 mL | |
| 10 mM | 0.0963 mL | 0.4817 mL | 0.9634 mL | 2.4084 mL | |
| 15 mM | 0.0642 mL | 0.3211 mL | 0.6422 mL | 1.6056 mL | |
| 20 mM | 0.0482 mL | 0.2408 mL | 0.4817 mL | 1.2042 mL | |
| 25 mM | 0.0385 mL | 0.1927 mL | 0.3853 mL | 0.9634 mL | |
| 30 mM | 0.0321 mL | 0.1606 mL | 0.3211 mL | 0.8028 mL | |
| 40 mM | 0.0241 mL | 0.1204 mL | 0.2408 mL | 0.6021 mL | |
| 50 mM | 0.0193 mL | 0.0963 mL | 0.1927 mL | 0.4817 mL | |
| 60 mM | 0.0161 mL | 0.0803 mL | 0.1606 mL | 0.4014 mL | |
| 80 mM | 0.0120 mL | 0.0602 mL | 0.1204 mL | 0.3010 mL |
MC-GGFG-AM-(10Me-11F-Camptothecin) Related Classifications
HY-153360 Related Classifications
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