2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. LASSBio-1911

LASSBio-1911 is a potent inhibitor of HDAC6. LASSBio-1911 shows antitumor in hepatocellular carcinoma (HCC) cells with minimal on normal cells.

For research use only. We do not sell to patients.

LASSBio-1911

LASSBio-1911 Chemical Structure

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LASSBio-1911 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

LASSBio-1911 is a potent inhibitor of HDAC6. LASSBio-1911 shows antitumor in hepatocellular carcinoma (HCC) cells with minimal on normal cells[1].

IC50 & Target

HDAC6

 

Cellular Effect
Cell Line Type Value Description References
HT-144 IC50
21.18 μM
Compound: 3c
Antiproliferative activity against human HT144 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Antiproliferative activity against human HT144 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 26705137]
HepG2 IC50
9.48 μM
Compound: 3c
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 26705137]
Molecular Weight

326.35

Formula

C17H18N4O3
SMILES

O=C(N/N=C/C1=CC=C(C(NO)=O)C=C1)C2=CC=C(N(C)C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LASSBio-1911 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LASSBio-1911LASSBio1911LASSBio 1911HDACHistone deacetylaseshepatocellular carcinoma (HCC)HepG2 cellHep3B cellInhibitorinhibitorinhibit

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