2. Others Apoptosis
  3. Fluorescent Dye Ferroptosis
  4. Mito-Rh-S

Mito-Rh-S is a ratiometric near-infrared (NIR) fluorescent probe that detects the fluctuation of mitochondrial HClO levels during ferroptosis in hepatocellular carcinoma (HCC).

For research use only. We do not sell to patients.

Mito-Rh-S

Mito-Rh-S Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
1 mg In-stock
5 mg In-stock
10 mg In-stock
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Mito-Rh-S Related Antibodies

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Description

Mito-Rh-S is a ratiometric near-infrared (NIR) fluorescent probe that detects the fluctuation of mitochondrial HClO levels during ferroptosis in hepatocellular carcinoma (HCC)[1].

In Vitro

Mito-Rh-S has an ultrafast response rate (2s) and large emission shift (115 nm). Mito-Rh-S has a high signal-to-noise ratio[1].
The cell experiments of Mito-Rh-S demonstrated that Fe2+- and Erastin-induced ferroptosis in HepG2 cells resulted in elevated levels of mitochondrial HClO[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mito-Rh-S Related Antibodies
Molecular Weight

743.26

Formula

C40H39ClN2O8S
Appearance

Solid

Color

Blue to dark blue

SMILES

O=Cl(=O)([O-])=O.CCN1C(C=CC=C2)=C2SC(C=C3/C=C4C5=[O+]C6=CC(N(CC)CC)=CC=C6C(C7=C(C(O)=O)C=CC=C7)=C5CCC/4)=C1C=C3OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (26.91 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3454 mL 6.7271 mL 13.4542 mL
5 mM 0.2691 mL 1.3454 mL 2.6908 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3454 mL 6.7271 mL 13.4542 mL 33.6356 mL
5 mM 0.2691 mL 1.3454 mL 2.6908 mL 6.7271 mL
10 mM 0.1345 mL 0.6727 mL 1.3454 mL 3.3636 mL
15 mM 0.0897 mL 0.4485 mL 0.8969 mL 2.2424 mL
20 mM 0.0673 mL 0.3364 mL 0.6727 mL 1.6818 mL
25 mM 0.0538 mL 0.2691 mL 0.5382 mL 1.3454 mL
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Mito-Rh-S Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mito-Rh-SFluorescent DyeFerroptosisHClO fluorescent probenear-infraredhepatocellular carcinomaInhibitorinhibitorinhibit

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