1. Protein Tyrosine Kinase/RTK
  2. Anaplastic lymphoma kinase (ALK)
  3. Ascrinvacumab

Ascrinvacumab  (Synonyms: Anti-ACVRL1 / ALK-1 Reference Antibody (ascrinvacumab); PF-03446962)

Cat. No.: HY-P99353 Purity: 97.45%
COA

Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a Kd value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC).

For research use only. We do not sell to patients.

Ascrinvacumab Chemical Structure

Ascrinvacumab Chemical Structure

CAS No. : 1463459-96-2

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Based on 1 publication(s) in Google Scholar

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Description

Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a Kd value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC)[1].

In Vitro

Ascrinvacumab binds to cellular human ALK1 with a Kd value of 7 nm[1].
Ascrinvacumab (30 min) blocks bone morphogenetic protein 9 (BMP9)- and fetal calf serum (FCS)-induced responses and mitigates BMP9-induced intensity and duration of Smad1 phosphorylation[1].
Ascrinvacumab (0.01-10 μg/mL; 2 h) inhibits BMP9 binding to ALK1[1].
Ascrinvacumab (40 μg/mL; 2 h) potently inhibits endothelial sprouting in human umbilical vein endothelial cells (HUVECs)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ascrinvacumab decreases human vessel density and improves antitumor efficacy when combined with bevacizumab (anti-VEGF) in mouse chimera tumor model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ascrinvacumab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 97.45%

References
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Ascrinvacumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Ascrinvacumab
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