2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR
  3. IGF-1R Akt mTOR
  4. Chromeceptin

Chromeceptin (94G6) is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR.

For research use only. We do not sell to patients.

Chromeceptin Chemical Structure

Chromeceptin Chemical Structure

CAS No. : 331859-86-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 99 In-stock
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Solid
5 mg USD 90 In-stock
10 mg USD 140 In-stock
25 mg USD 290 In-stock
50 mg USD 420 In-stock
100 mg USD 650 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Chromeceptin Related Antibodies

Top Publications Citing Use of Products

View All Akt Isoform Specific Products:

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Akt Akt1 Akt2 Akt3

View All mTOR Isoform Specific Products:

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mTOR mTORC1 mTORC2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Chromeceptin (94G6) is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR[1].

In Vitro

Chromeceptin (94G6) (5 µM) inhibits IGF2 expression in Hep3B-derived TS cells in a time-dependent manner[1].
Chromeceptin decreases the Phosphorylation levels of protein kinase B (AKT, Ser463) and rapamycin (mTOR, Ser 2481 and Ser 2448) in TS cells[1].
Chromeceptin represses the phosphorylation at ser371 in mTOR effectors ribosomal protein S6 kinase (p70S6K)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chromeceptin Related Antibodies
Molecular Weight

359.35

Formula

C19H16F3N3O
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

N#CC1=C(N)OC2=CC(N(C)C)=CC=C2C1C3=CC=CC(C(F)(F)F)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (278.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7828 mL 13.9140 mL 27.8280 mL
5 mM 0.5566 mL 2.7828 mL 5.5656 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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V1

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C2

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V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  50% PEG300    50% Saline

    Solubility: 10 mg/mL (27.83 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7828 mL 13.9140 mL 27.8280 mL 69.5701 mL
5 mM 0.5566 mL 2.7828 mL 5.5656 mL 13.9140 mL
10 mM 0.2783 mL 1.3914 mL 2.7828 mL 6.9570 mL
15 mM 0.1855 mL 0.9276 mL 1.8552 mL 4.6380 mL
20 mM 0.1391 mL 0.6957 mL 1.3914 mL 3.4785 mL
25 mM 0.1113 mL 0.5566 mL 1.1131 mL 2.7828 mL
30 mM 0.0928 mL 0.4638 mL 0.9276 mL 2.3190 mL
40 mM 0.0696 mL 0.3479 mL 0.6957 mL 1.7393 mL
50 mM 0.0557 mL 0.2783 mL 0.5566 mL 1.3914 mL
60 mM 0.0464 mL 0.2319 mL 0.4638 mL 1.1595 mL
80 mM 0.0348 mL 0.1739 mL 0.3479 mL 0.8696 mL
100 mM 0.0278 mL 0.1391 mL 0.2783 mL 0.6957 mL
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Chromeceptin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chromeceptin331859-86-094G6IGF-1RAktmTORInsulin-like growth factor-1 receptorPKBProtein kinase BMammalian target of Rapamycinbenzochromene derivativeHep3B cellsTS cellsAKTInhibitorinhibitorinhibit

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