PI3Kα-IN-22
PI3Kα-IN-22 (Compound 17) is an orally active, potent and selective inhibitor of PI3KαH1047R, with an IC50 of 1 nM for pAKT T47D AlphaLISA. PI3Kα-IN-22 can induce tumor regressions in the HCC1954 tumor model in mice.
For research use only. We do not sell to patients.
- CAS No.: 2925030-26-6
- Formula: C24H23F2N5O3
- Molecular Weight:467.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SK-BR-3 | IC50 |
8972 nM
Compound: 17
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Cytotoxicity against human SK-BR-3 cells harboring wildtype PI3Kalpha assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo 2.0 luminescent cell viability assay
Cytotoxicity against human SK-BR-3 cells harboring wildtype PI3Kalpha assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo 2.0 luminescent cell viability assay
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[PMID: 38477582] |
| T47D | IC50 |
48 nM
Compound: 17
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Cytotoxicity against human T47D cells harboring PI3Kalpha H1047R mutant assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo 2.0 luminescent cell viability assay
Cytotoxicity against human T47D cells harboring PI3Kalpha H1047R mutant assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo 2.0 luminescent cell viability assay
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[PMID: 38477582] |
Chemical Information
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CAS No. 2925030-26-6
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Molecular Weight 467.47
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Formula C24H23F2N5O3
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SMILES
CC(C=C([C@H](NC1=CC=CC=C1C(O)=O)C)C2=NC(N3CCC(F)(F)CC3)=C4C#N)=CN2C4=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3Kα-IN-22 Related Classifications
HY-161373 Related Classifications
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