anti-TNBC agent-7
anti-TNBC agent-7 (Compound 13c) possesses anticancer activity, serving as a molecular probe to recognize and regulate the signal transduction of the USP21/JAK2/STAT3 axis, exhibiting nanomolar-level cytotoxicity against MDA-MB-231 and HCC-1806 cancer cells, effectively combating triple-negative breast cancer (TNBC).
For research use only. We do not sell to patients.
- Formula: C26H24F3N3O4
- Molecular Weight:499.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCC1806 | IC50 |
0.25 μM
Compound: 13c
|
Anti-proliferative activity against human HCC1806 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anti-proliferative activity against human HCC1806 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 38776807] |
| Hs-578T | IC50 |
0.59 μM
Compound: 13c
|
Anti-proliferative activity against human Hs-578T cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anti-proliferative activity against human Hs-578T cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 38776807] |
| MCF7 | IC50 |
1.45 μM
Compound: 13c
|
Anti-proliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anti-proliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 38776807] |
| MDA-MB-231 | IC50 |
0.19 μM
Compound: 13c
|
Anti-proliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Anti-proliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 38776807] |
Chemical Information
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Molecular Weight 499.48
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Formula C26H24F3N3O4
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SMILES
COC1=CC(NC2=C(C=CC(F)=C2)C(NCCC3=CNC4=C(C=CC(F)=C34)F)=O)=CC(OC)=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)