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Cat. No.: HY-155046

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FGFR4-IN-14

FGFR4-IN-14 (Compound 27i) is a FGFR4 inhibitor (IC₅₀: 2.4 nM. FGFR4-IN-14 inhibits the proliferation of V550L and N535K mutant strains, with IC₅₀s of 21 nM, 2.5 nM, 171 nM against huh7, BaF3/ETV6-FGFR4-V550L and BaF3/ETV6-FGFR4-N535K cells respectively. FGFR4-IN-14 has potent antitumor efficacy in the Huh7 xenograft model. FGFR4-IN-14 can be used for research of hepatocellular carcinoma (HCC).

For research use only. We do not sell to patients.

CAS No.: 3027827-02-4
Formula: C₂₇H₂₅Cl₂N₅O₂
Molecular Weight:522.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

FGFR4-IN-14 Chemical Structure

CAS No.: 3027827-02-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	0.002 μM Compound: 27i	Antiproliferative activity against mouse BaF3 cells harbouring ETV6-FGFR4-V550L mutant measured after 24 to 48 hrs by MTT assay Antiproliferative activity against mouse BaF3 cells harbouring ETV6-FGFR4-V550L mutant measured after 24 to 48 hrs by MTT assay	[PMID: 37437349]
BaF3	IC₅₀	0.172 μM Compound: 27i	Antiproliferative activity against mouse BaF3 cells harbouring ETV6-FGFR4-N535K mutant measured after 24 to 48 hrs by MTT assay Antiproliferative activity against mouse BaF3 cells harbouring ETV6-FGFR4-N535K mutant measured after 24 to 48 hrs by MTT assay	[PMID: 37437349]
Hep 3B2	IC₅₀	0.038 μM Compound: 27i	Antiproliferative activity against human Hep3B cells measured after 24 to 48 hrs by MTT assay Antiproliferative activity against human Hep3B cells measured after 24 to 48 hrs by MTT assay	[PMID: 37437349]
HepG2	IC₅₀	>5 μM Compound: 27i	Antiproliferative activity against human HepG2 cells measured after 24 to 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells measured after 24 to 48 hrs by MTT assay	[PMID: 37437349]
Huh-7	IC₅₀	21 nM Compound: 27i	Antiproliferative activity against human Huh-7 cells measured after 24 to 48 hrs by MTT assay Antiproliferative activity against human Huh-7 cells measured after 24 to 48 hrs by MTT assay	[PMID: 37437349]
L02	IC₅₀	>10 μM Compound: 27i	Antiproliferative activity against human L02 cells measured after 24 to 48 hrs by MTT assay Antiproliferative activity against human L02 cells measured after 24 to 48 hrs by MTT assay	[PMID: 37437349]

Chemical Information

CAS No. 3027827-02-4
Molecular Weight 522.43
Formula C₂₇H₂₅Cl₂N₅O₂
SMILES

C=CC(NC1=CC2=C(C=C1C3=NNC4=C3C=C(O[C@@H](C5=C(Cl)C=NC=C5Cl)C)C=C4)CCN(C)C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang Y, et al. Design, synthesis and biological evaluation of indazole derivatives as selective covalent inhibitors of FGFR4 in wild-type and gatekeeper mutants. Eur J Med Chem. 2023 Oct 5;258:115628. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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