3027827-02-4
Chemical Structure
FGFR4-IN-14
- CAS No.: 3027827-02-4
- Formula:C27H25Cl2N5O2
- Molecular Weight:522.43
InChIKey: CUWHIVQOEAZHGI-OAHLLOKOSA-N
SMILES: C=CC(NC1=CC2=C(C=C1C3=NNC4=C3C=C(O[C@@H](C5=C(Cl)C=NC=C5Cl)C)C=C4)CCN(C)C2)=O
Biological Activity: FGFR4-IN-14 (Compound 27i) is a FGFR4 inhibitor (IC50: 2.4 nM. FGFR4-IN-14 inhibits the proliferation of V550L and N535K mutant strains, with IC50s of 21 nM, 2.5 nM, 171 nM against huh7, BaF3/ETV6-FGFR4-V550L and BaF3/ETV6-FGFR4-N535K cells respectively. FGFR4-IN-14 has potent antitumor efficacy in the Huh7 xenograft model. FGFR4-IN-14 can be used for research of hepatocellular carcinoma (HCC)[1].
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FGFR4-IN-14 | FGFR4-IN-14 (Compound 27i) is a FGFR4 inhibitor (IC50: 2.4 nM. FGFR4-IN-14 inhibits the proliferation of V550L and N535K mutant strains, with IC50s of 21 nM, 2.5 nM, 171 nM against huh7, BaF3/ETV6-FGFR4-V550L and BaF3/ETV6-FGFR4-N535K cells respectively. FGFR4-IN-14 has potent antitumor efficacy in the Huh7 xenograft model. FGFR4-IN-14 can be used for research of hepatocellular carcinoma (HCC). | |||||||||||||||||||||
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Keywords
