2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR4-IN-6

FGFR4-IN-6 (Compound 9ka) is a covalently reversible FGFR4 inhibitor with an IC50 value of 5.4 nM. FGFR4-IN-6 also exhibits good oral pharmacokinetic properties. FGFR4-IN-6 induces significant tumor regressions in a xenograft mouse model of Hep3B2.1-7 HCC cell line without an obvious sign of toxicity. FGFR4-IN-6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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FGFR4-IN-6 Chemical Structure

FGFR4-IN-6 Chemical Structure

CAS No. : 2760970-10-1

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FGFR4-IN-6 Related Antibodies

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Description

FGFR4-IN-6 (Compound 9ka) is a covalently reversible FGFR4 inhibitor with an IC50 value of 5.4 nM. FGFR4-IN-6 also exhibits good oral pharmacokinetic properties. FGFR4-IN-6 induces significant tumor regressions in a xenograft mouse model of Hep3B2.1-7 HCC cell line without an obvious sign of toxicity[1]. FGFR4-IN-6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Molecular Weight

567.64

Formula

C31H33N7O4
CAS No.
SMILES

O=C(N1CCCC2=CC(CN3C(CN(CC3)C)=O)=C(N=C21)C=O)NC4=CC(OC(C)C)=C(C=N4)C#CC5=CC=CN=C5
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FGFR4-IN-6 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR4-IN-62760970-10-1FGFRFibroblast growth factor receptorcovalently reversibleFGFR4 inhibitorgood oral pharmacokinetic propertiestumor regressionsInhibitorinhibitorinhibit

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