2. Apoptosis
  3. IAP
  4. BV6 TFA

BV6 TFA is an antagonist of cIAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family. BV6 TFA shows an IC50 of 7.2 μM in MTS assays in HCC193 cells. BV6 TFA can be used in the research of endometrial cancer and endometriosis.

For research use only. We do not sell to patients.

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Based on 22 publication(s) in Google Scholar

Other Forms of BV6 TFA:

BV6 TFA Related Antibodies

Top Publications Citing Use of Products

    BV6 TFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2018 Mar 19;9(1):1136.   [Abstract]

    Western Blot analysis of p52, p100, NIK, c-IAP2, Peli1, and HSP60 in total lysis of control and Peli1-knockdown M12 cells that pretreated with DMSO or smac mimetic BV6 for 4 h, and then stimulated with anti-CD40 (αCD40) at the indicated time points.

    BV6 TFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2018 Mar 19;9(1):1136.   [Abstract]

    Western Blot analysis of p52, p100, NIK, c-IAP2, Peli1, and HSP60 in total lysis of control and Peli1-knockdown M12 cells that pretreated with DMSO or smac mimetic BV6 for 4 h, and then stimulated with BAFF at the indicated time points.

    BV6 TFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2018 Mar 19;9(1):1136.   [Abstract]

    Analysis of Lys48 ubiquitination of NIK in control and Peli1-knockdown M12 cells that pretreated with DMSO or smac mimetic BV6 for 4 h, then left unstimulated or stimulated with anti-CD40 (αCD40) for 4 h in the presence of MG132.

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    cIAP cIAP-1 cIAP-2 XIAP

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    Description

    BV6 TFA is an antagonist of cIAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family. BV6 TFA shows an IC50 of 7.2 μM in MTS assays in HCC193 cells. BV6 TFA can be used in the research of endometrial cancer and endometriosis[1][2].

    In Vitro

    BV6 TFA (250 nM-30 μM, 24 h) induces apoptosis in HCC193 and H460 lung cancer cell lines in a concentration- and time-dependent manner. BV6 TFA (250 nM-30 μM, 24 h) can also enhance the sensitivity of HCC193 and H460 cell lines to radiation[1].
    BV6 TFA (1μM 24 h; 5 μM, 48 h) significantly sensitizes the cell to radiation (HCC193-DER=1.38, at 1μM BV6; H460-DER=1.42, at 5μM BV6)[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    BV6 TFA Related Antibodies

    Cell Proliferation Assay[1]

    Cell Line: HCC193 cells, H460 cells
    Concentration: 250 nM, 500 nM, 1 μM, 3 μM, 5 μM, 10 μM, 20 μM, 30 μM
    Incubation Time: 24 hours
    Result: Decreased cell survival percentage for HCC193 with an IC50 of 7.2μM.
    Decreased the cell viability of H460 cells by about 60% at 30 μM.

    Western Blot Analysis[1]

    Cell Line: HCC193 cells, H460 cells
    Concentration: 0.25 μM, 0.5 μM, 1 μM, 5 μM
    Incubation Time: 1, 14, 24 hours
    Result: Reduced the expression of cIAP1 within one hour and gradually decreased XIAP with increased incubation time for both cell lines.
    Reduced the expression of cIAP1 with 0.25μM and gradually decreased XIAP with increasing concentration for both cell lines.

    ELISA Assay[1]

    Cell Line: HCC193 cells, H460 cells
    Concentration: 1 μM, 5 μM
    Incubation Time: 12 hours
    Result: Induced enhancement of the secretion of TNFα in HCC193 cells.
    Did not enhance the secretion of TNFα in H460 cells.
    In Vivo

    BV6 TFA (10 mg/kg, twice weekly for 4 weeks, i.p.) attenuates the intensity of IAPs expression[2].
    BV6 TFA (10 mg/kg, twice weekly for 4 weeks, i.p.) reduces the total number of lesions and the percentage of Ki67-positive cells compared to the control[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female endometriosis mice modeling by Estradiol valerate (HY-B0672) at the dosage 0.5 µg/mouse/week s.c injected (6 weeks of age, BALB/c).
    Dosage: 10 mg/kg
    Administration: a single i.p. injection,twice weekly for 4 weeks
    Result: Attenuated the intensity of IAPs expression.
    Molecular Weight

    1205.57 (free base)

    Formula

    C70H96N10O8·xC2HF3O2
    Appearance

    Solid

    SMILES

    O=C(NCCCCCCNC([C@@H](NC([C@H](CCC1)N1C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)=O)C(C3=CC=CC=C3)C4=CC=CC=C4)=O)[C@@H](NC([C@H](CCC5)N5C([C@H](C6CCCCC6)NC([C@H](C)NC)=O)=O)=O)C(C7=CC=CC=C7)C8=CC=CC=C8.OC(C(F)(F)F)=O.[x]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Purity & Documentation
    References
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    BV6 TFA Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    BV6BV 6BV-6IAPcIAP1XIAPapoptosisHCC193Inhibitorinhibitorinhibit

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