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Cat. No.: HY-175553

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VEGFR-2-IN-72

VEGFR-2-IN-72 is a selective VEGFR-2 inhibitor with an IC₅₀ of 22.2 nM. VEGFR-2-IN-72 exhibits anticancer activity against HepG2 and Hep3B human HCC cell lines with IC₅₀s of 15.7 and 2.4 μM. VEGFR-2-IN-72 can cause a mild blockage of the cell cycle and induce cell aopoptosis. VEGFR-2-IN-72 can used for the study of hepatocellular carcinoma (HCC).

For research use only. We do not sell to patients.

Formula: C₃₀H₃₀N₄O₄
Molecular Weight:510.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

VEGFR-2-IN-72 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

VEGFR-2

22.2 nM (IC₅₀)

All VEGFR Isoforms :

In Vitro

VEGFR-2-IN-72 (Compound 3i) (0.5-5 μM, 24 h) inhibits the colony formation abilities, induces apoptosis in Hep3B cells through the mitochondrial pathway, and causes a mild delay in the S phase of Hep3B cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Hep3B cells
Concentration:

0.5 and 5 μM
Incubation Time:

24 h
Result:

Significantly increased the proportion of apoptotic cells, with a better effect than Lenvatinib (HY-10981).

Cell Cycle Analysis^[1]

Cell Line:

Hep3B cells
Concentration:

0.5 and 5 μM
Incubation Time:

24 h
Result:

Caused a mild delay in the S phase of Hep3B cells, but its effect on the cell cycle was weaker than its role in inducing apoptosis.

Western Blot Analysis^[1]

Cell Line:

Hep3B cells
Concentration:

0.5 and 5 μM
Incubation Time:

24 h
Result:

Increased the expression of caspase 3 and Bax, decreased the expression of Bcl-2, and increase the ratio of Bax/Bcl-2.

Chemical Information

Molecular Weight 510.58
Formula C₃₀H₃₀N₄O₄
SMILES

O=C(C1=C(OC)C=C2N=CC=C(OC3=CC(C4=CC=CC(C(C)C)=C4)=C(NC(NC5CC5)=O)C=C3)C2=C1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sun L, et al. Design, synthesis, and anti-hepatocellular carcinoma activity evaluation of aryl Lenvatinib derivatives: Exploring potential VEGFR-2 inhibitors. Bioorg Chem. 2025 Jul 26;164:108799. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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VEGFR-2-IN-72

All VEGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

VEGFR-2-IN-72 Related Classifications

HY-175553 Related Classifications