EGFR-IN-122
Based on 1 Customer Validation
EGFR-IN-122 (compound Yfq07) is a potent EGFR inhibitor. EGFR-IN-122 suppresses the proliferation of PC-9GR and HCC827GR cells.
For research use only. We do not sell to patients.
- Purity: 99.98%
- CAS No.: 1807453-44-6
- Formula: C19H20N4O3
- Molecular Weight:352.39
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
All EGFR Isoforms
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Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
0.74 μM
Compound: Yfq07
|
Antiproliferative activity against human A431 cells after 72 hrs by MTT assay
Antiproliferative activity against human A431 cells after 72 hrs by MTT assay
|
[PMID: 30195240] |
| BEAS-2B | IC50 |
21.43 μM
Compound: Yfq07
|
Cytotoxicity against human BEAS2B cells after 72 hrs by MTT assay
Cytotoxicity against human BEAS2B cells after 72 hrs by MTT assay
|
[PMID: 30195240] |
| HCC827 | IC50 |
1.14 μM
Compound: Yfq07
|
Antiproliferative activity against human HCC827 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCC827 cells after 72 hrs by MTT assay
|
[PMID: 30195240] |
| NCI-H1975 | IC50 |
0.89 μM
Compound: Yfq07
|
Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay
|
[PMID: 30195240] |
| NCI-H3255 | IC50 |
0.86 μM
Compound: Yfq07
|
Antiproliferative activity against human H3255 cells after 72 hrs by MTT assay
Antiproliferative activity against human H3255 cells after 72 hrs by MTT assay
|
[PMID: 30195240] |
| PC-9 | IC50 |
0.45 μM
Compound: Yfq07
|
Antiproliferative activity against human PC9 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC9 cells after 72 hrs by MTT assay
|
[PMID: 30195240] |
Chemical Information
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CAS No. 1807453-44-6
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Appearance Solid
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Molecular Weight 352.39
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Formula C19H20N4O3
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Color White to off-white
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SMILES
COC1=CC(NC2=CC(NC3=CC(OC)=CC=C3)=NC=N2)=C(OC)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)