EGFR-IN-122
Based on 1 Customer Validation
EGFR-IN-122 (compound Yfq07) is a potent EGFR inhibitor. EGFR-IN-122 suppresses the proliferation of PC-9GR and HCC827GR cells.
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- Purity : 99.98%
- CAS No.: 1807453-44-6
- 화학식: C19H20N4O3
- 분자량:352.39
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보관:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
0.74 μM
Compound: Yfq07
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Antiproliferative activity against human A431 cells after 72 hrs by MTT assay
Antiproliferative activity against human A431 cells after 72 hrs by MTT assay
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[PMID: 30195240] |
| BEAS-2B | IC50 |
21.43 μM
Compound: Yfq07
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Cytotoxicity against human BEAS2B cells after 72 hrs by MTT assay
Cytotoxicity against human BEAS2B cells after 72 hrs by MTT assay
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[PMID: 30195240] |
| HCC827 | IC50 |
1.14 μM
Compound: Yfq07
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Antiproliferative activity against human HCC827 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCC827 cells after 72 hrs by MTT assay
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[PMID: 30195240] |
| NCI-H1975 | IC50 |
0.89 μM
Compound: Yfq07
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Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay
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[PMID: 30195240] |
| NCI-H3255 | IC50 |
0.86 μM
Compound: Yfq07
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Antiproliferative activity against human H3255 cells after 72 hrs by MTT assay
Antiproliferative activity against human H3255 cells after 72 hrs by MTT assay
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[PMID: 30195240] |
| PC-9 | IC50 |
0.45 μM
Compound: Yfq07
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Antiproliferative activity against human PC9 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC9 cells after 72 hrs by MTT assay
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[PMID: 30195240] |
Chemical Information
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CAS No. 1807453-44-6
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Appearance Solid
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분자량 352.39
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화학식 C19H20N4O3
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Color White to off-white
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SMILES
COC1=CC(NC2=CC(NC3=CC(OC)=CC=C3)=NC=N2)=C(OC)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
용액&용해도
In Vitro:
DMSO : 4.55 mg/mL (12.91 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
순도&문서
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8378 mL | 14.1888 mL | 28.3776 mL | 70.9441 mL |
| 5 mM | 0.5676 mL | 2.8378 mL | 5.6755 mL | 14.1888 mL | |
| 10 mM | 0.2838 mL | 1.4189 mL | 2.8378 mL | 7.0944 mL |
EGFR-IN-122 Related Classifications
HY-162890 Related Classifications
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