Nur77 antagonist 2
Nur77 antagonist 2 (Compound 12b) is an orally active Nur77 antagonist with a KD value of 0.42 μM. Nur77 antagonist 2 exhibits proliferative activity on liver cancer cells. Nur77 antagonist 2 stabilizes Nur77 by inhibiting its ubiquitin-proteasomal degradation, leading to Nur77-dependent apoptosis via the ASK1-JNK/p38 pathway. Nur77 antagonist 2 inhibits tumor growth in the HCCLM3 xenograft model. Nur77 antagonist 2 can be used for the study of hepatocellular carcinoma (HCC).
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- Formule: C26H21N7O
- Masse moléculaire:447.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Activité biologique
Description
IC50 & Target
[1]|
Nur77/NR4A1 0.42 μM (Kd) |
Chemical Information
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Masse moléculaire 447.49
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Formule C26H21N7O
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SMILES
O=C(N/N=C/C1=CC(C)=CC=C1)C(N2)=CC3=C2C=CC(NC4=NC=CC(C5=CC=NC=C5)=N4)=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nur77 antagonist 2 Related Classifications
HY-179033 Related Classifications
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Keywords
- Nur77 antagonist 2
- Nuclear Hormone Receptor 4A/NR4A
- Apoptosis
- ASK1
- JNK
- p38 MAPK
- Nuclear Hormone Receptor 4A
- Nerve Growth Factor IB-like Receptor
- Apoptosis signal-regulating kinase 1
- MAP3K5
- MAPKKK5
- Mitogen-activated protein kinase kinase kinase 5
- MEK kinase 5
- c-Jun N-terminal kinase
- Hepatocellular carcinoma
- Nur77
- 1H-Indole-2-carbohydrazide
- ASK1-JNK/P38
- Inhibitor
- inhibitor
- inhibit