Nur77 antagonist 2
Nur77 antagonist 2 (Compound 12b) is an orally active Nur77 antagonist with a KD value of 0.42 μM. Nur77 antagonist 2 exhibits proliferative activity on liver cancer cells. Nur77 antagonist 2 stabilizes Nur77 by inhibiting its ubiquitin-proteasomal degradation, leading to Nur77-dependent apoptosis via the ASK1-JNK/p38 pathway. Nur77 antagonist 2 inhibits tumor growth in the HCCLM3 xenograft model. Nur77 antagonist 2 can be used for the study of hepatocellular carcinoma (HCC).
For research use only. We do not sell to patients.
- Formula: C26H21N7O
- Molecular Weight:447.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
All Nuclear Hormone Receptor 4A/NR4A Isoforms
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Biological Activity
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Nur77/NR4A1 0.42 μM (Kd) |
Chemical Information
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Molecular Weight 447.49
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Formula C26H21N7O
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SMILES
O=C(N/N=C/C1=CC(C)=CC=C1)C(N2)=CC3=C2C=CC(NC4=NC=CC(C5=CC=NC=C5)=N4)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nur77 antagonist 2 Related Classifications
HY-179033 Related Classifications
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