ERK1/2 inhibitor 13
ERK1/2 inhibitor 13 (Compound 21y) is the orally active inhibitor for ERK that inhibits ERK1 and ERK2 with IC50 of 91.71 nM and 97.87 nM. ERK1/2 inhibitor 13 inhibits the proliferation of MCF-7, 4T1, MDA-MB-468, and HCC1970 (IC50 of 0.67, 2.76, 2.15 and 1.68 μM), inhibits the cancer cell migration, induces apoptosis and autophagy in MCF-7. ERK1/2 inhibitor 13 exhibits antitumor and anti-metastatic effect in 4T1 xenograft mouse model.
For research use only. We do not sell to patients.
- CAS No.: 3093367-23-5
- Formula: C36H29BrF6N4O
- Molecular Weight:727.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ERK1 91.71 nM (IC50) |
ERK2 97.87 nM (IC50) |
Chemical Information
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CAS No. 3093367-23-5
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Molecular Weight 727.54
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Formula C36H29BrF6N4O
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SMILES
FC(F)(C1=CC(NC(N[C@@H](CC2=CC=CC=C2)CN3C=[N+](CC4=CC=CC5=C4C=CC=C5)C6=C3C=CC=C6)=O)=CC(C(F)(F)F)=C1)F.[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ERK1/2 inhibitor 13 Related Classifications
HY-173060 Related Classifications
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