1. Metabolic Enzyme/Protease
    Apoptosis
  2. Endogenous Metabolite
    Apoptosis
  3. Glycochenodeoxycholic acid

Glycochenodeoxycholic acid (Synonyms: Chenodeoxycholylglycine)

Cat. No.: HY-N2334 Purity: >98.0%
Handling Instructions

Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis.

For research use only. We do not sell to patients.

Glycochenodeoxycholic acid Chemical Structure

Glycochenodeoxycholic acid Chemical Structure

CAS No. : 640-79-9

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10 mM * 1  mL in DMSO USD 66 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis[1][2].

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

449.62

Formula

C₂₆H₄₃NO₅

CAS No.

640-79-9

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (222.41 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2241 mL 11.1205 mL 22.2410 mL
5 mM 0.4448 mL 2.2241 mL 4.4482 mL
10 mM 0.2224 mL 1.1121 mL 2.2241 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.56 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.56 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.56 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[3]

Rats: The freshly isolated hepatocytes are preincubated for 2 h at a density of 1× 106 cells/mL in a mixture of William’s E medium supplement with 10% FBS. Isolated rat hepatocytes are incubated in William’s E medium with or without (used as a control) GCDCA (50, 100 and 300 μM), or TG (1, 2 and 5 μM) for 1-24 h[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: >98.0%

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Keywords:

Glycochenodeoxycholic acidChenodeoxycholylglycineEndogenous MetaboliteApoptosisInhibitorinhibitorinhibit

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Glycochenodeoxycholic acid
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