1. Metabolic Enzyme/Protease
    Apoptosis
  2. Endogenous Metabolite
    Bcl-2 Family
  3. Glycocholic acid

Glycocholic acid 

Cat. No.: HY-N1423 Purity: >97.0%
Handling Instructions

Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways.

For research use only. We do not sell to patients.

Glycocholic acid Chemical Structure

Glycocholic acid Chemical Structure

CAS No. : 475-31-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg USD 50 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways.

IC50 & Target[1]

Bax

 

Bcl-2

 

MDR1

 

MRP1

 

MDR2

 

Human Endogenous Metabolite

 

In Vitro

Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways[1].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (214.77 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1477 mL 10.7384 mL 21.4767 mL
5 mM 0.4295 mL 2.1477 mL 4.2953 mL
10 mM 0.2148 mL 1.0738 mL 2.1477 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.37 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.37 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.37 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

465.62

Formula

C₂₆H₄₃NO₆

CAS No.

475-31-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >97.0%

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Product Name:
Glycocholic acid
Cat. No.:
HY-N1423
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Glycocholic acid

Cat. No.: HY-N1423