Glycocholic acid-d4
Based on 1 Customer Validation
Glycocholic acid-d4 is the deuterium labeled Glycocholic acid (HY-N1423). Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 1201918-15-1
- Formula: C26H39D4NO6
- Molecular Weight:469.65
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 1201918-15-1
-
Unlabeled Cas 475-31-0
-
Appearance Solid
-
Molecular Weight 469.65
-
Formula C26H39D4NO6
-
Color White to off-white
-
SMILES
O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@]([C@H](C)CCC(NCC(O)=O)=O)([H])CC3)([C@@H](O)C[C@]2([H])[C@]4(C)[C@](C([2H])([2H])[C@H](O)C([2H])([2H])C4)([H])C1)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (212.92 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (399 KB)
- English - EN (399 KB)
- Français - FR (399 KB)
- Deutsch - DE (399 KB)
- Norwegian - NO (399 KB)
- Español - ES (399 KB)
- Swedish - SV (399 KB)
- Italian - IT (399 KB)
- Korean - KR (399 KB)
- Portuguese - PT (399 KB)
-
Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Lo YL, et al. Inhibit multidrug resistance and induce apoptosis by using glycocholic acid and epirubicin. Eur J Pharm Sci. 2008 Sep 2;35(1-2):52-67. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1292 mL | 10.6462 mL | 21.2925 mL | 53.2311 mL |
| 5 mM | 0.4258 mL | 2.1292 mL | 4.2585 mL | 10.6462 mL | |
| 10 mM | 0.2129 mL | 1.0646 mL | 2.1292 mL | 5.3231 mL | |
| 15 mM | 0.1419 mL | 0.7097 mL | 1.4195 mL | 3.5487 mL | |
| 20 mM | 0.1065 mL | 0.5323 mL | 1.0646 mL | 2.6616 mL | |
| 25 mM | 0.0852 mL | 0.4258 mL | 0.8517 mL | 2.1292 mL | |
| 30 mM | 0.0710 mL | 0.3549 mL | 0.7097 mL | 1.7744 mL | |
| 40 mM | 0.0532 mL | 0.2662 mL | 0.5323 mL | 1.3308 mL | |
| 50 mM | 0.0426 mL | 0.2129 mL | 0.4258 mL | 1.0646 mL | |
| 60 mM | 0.0355 mL | 0.1774 mL | 0.3549 mL | 0.8872 mL | |
| 80 mM | 0.0266 mL | 0.1331 mL | 0.2662 mL | 0.6654 mL | |
| 100 mM | 0.0213 mL | 0.1065 mL | 0.2129 mL | 0.5323 mL |
Glycocholic acid-d4 Related Classifications
HY-N1423S Related Classifications
Powered by Bioz