Glycochenodeoxycholic acid (Standard)
Based on 1 Customer Validation
Glycochenodeoxycholic acid (Standard) is the analytical standard of Glycochenodeoxycholic acid. This product is intended for research and analytical applications. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC)[1][2][3][4].
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- Pureté: 99.77%
- CAS No.: 640-79-9
- Formule: C26H43NO5
- Masse moléculaire:449.62
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
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HY-125731R
Glycodeoxycholic Acid (Standard) -
HY-N2334
Glycochenodeoxycholic acid -
HY-N0169R
Hyodeoxycholic acid (Standard) -
HY-N2027R
Taurochenodeoxycholic acid (Standard) -
HY-N0191
Andrographolide -
HY-N0324
Cholic acid -
HY-19696
Tauroursodeoxycholate -
HY-B0172
Lithocholic acid -
HY-13771
Ursodeoxycholic acid -
HY-76847
Chenodeoxycholic Acid -
HY-N1423
Glycocholic acid -
HY-125731
Glycodeoxycholic acid
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 640-79-9
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Appearance Solid
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Masse moléculaire 449.62
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Formule C26H43NO5
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Color White to off-white
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SMILES
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCC(O)=O)=O)([H])[C@@]3([H])[C@]([C@@]4([C@](C[C@H](O)CC4)([H])C[C@H]3O)C)([H])CC1
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Synonyms
Chenodeoxycholylglycine (Standard)
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Lan W, et al. Glycochenodeoxycholic acid impairs transcription factor E3 -dependent autophagy-lysosome machinery by disrupting reactive oxygen species homeostasis in L02 cells[J]. Toxicol Lett. 2020 Oct 1;331:11-21. [Content Brief]
[2]. Wang A, et al. Glycochenodeoxycholic Acid Does Not Increase Transforming Growth Factor-Beta Expression in Bile Duct Epithelial Cells or Collagen Synthesis in Myofibroblasts[J]. J Clin Exp Hepatol. 2017 Dec;7(4):316-320. [Content Brief]
[3]. Gonzalez B, et al. Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. Mol Cell Biochem. 2000 Apr;207(1-2):19-27. [Content Brief]
[4]. Shi C, et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells[J]. Aging (Albany NY). 2020 Aug 3;12(15):15546-15555. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glycochenodeoxycholic acid (Standard) Related Classifications
HY-N2334R Related Classifications
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Keywords
- Glycochenodeoxycholic acid (Standard)
- 640-79-9
- Chenodeoxycholylglycine (Standard)
- Reference Standards
- Interleukin Related
- Apoptosis
- STAT
- Endogenous Metabolite
- Caspase
- BCL6
- bile salt
- hepatocellular carcinoma cells
- autophagosome inhibition
- STAT3 signaling pathway
- cholestasis desease
- primary sclerosing cholangitis
- Inhibitor
- inhibitor
- inhibit