2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. VEGFR-IN-4

VEGFR-IN-4 (Compound 6e) is an epidermal growth factor receptor (EGFR) inhibitor. VEGFR-IN-4 has potent antiproliferative activity with an IC50 value of 24.6nM against HCC827 cells.

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VEGFR-IN-4

VEGFR-IN-4 Chemical Structure

CAS No. : 3000483-29-1

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VEGFR-IN-4 Related Antibodies

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Description

VEGFR-IN-4 (Compound 6e) is an epidermal growth factor receptor (EGFR) inhibitor. VEGFR-IN-4 has potent antiproliferative activity with an IC50 value of 24.6nM against HCC827 cells[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.703 μM
Compound: 6e
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 38169271]
HCC827 IC50
0.025 μM
Compound: 6e
Antiproliferative activity against human HCC827 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human HCC827 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 38169271]
HCC827 IC50
24.6 nM
Compound: 6e
Inhibition of colony formation in human HCC827 cells measured after 14 days by crystal violet staining based analysis
Inhibition of colony formation in human HCC827 cells measured after 14 days by crystal violet staining based analysis
[PMID: 38169271]
L02 IC50
2.45 μM
Compound: 6e
Cytotoxicity against human L02 cells assessed as inhibition of cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as inhibition of cell viability measured after 72 hrs by MTT assay
[PMID: 38169271]
NCI-H1975 IC50
0.168 μM
Compound: 6e
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 38169271]
Molecular Weight

446.91

Formula

C19H19ClN6O3S
CAS No.
SMILES

ClC1=CN=C(NC2=CC=C(N3CCOCC3)C=C2)N=C1NC4=C(C(NO)=O)SC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VEGFR-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-IN-43000483-29-1EGFREpidermal growth factor receptorErbB-1HER1EGFR InhibitorInhibitorinhibitorinhibit

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