SL44
Based on 1 Customer Validation
SL44 is an agonist for human caseinolytic protease P (HsClpP), with an EC50 of 1.30 μM. SL44 inhibits the proliferation of LM3 with an IC50 of 3.1 μM. SL44 induces apoptosis in HCC cells, through the degradation of respiratory chain complex subunits. SL44 exhibits antitumor efficacy in mouse models without obvious toxicity (LD50=400 mg/kg). SL44 exhibits good pharmacokinetic characters in rat models.
For research use only. We do not sell to patients.
- Purity: 99.57%
- CAS No.: 3054715-45-3
- Formula: C22H20ClFN4O
- Molecular Weight:410.87
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCCLM3 | IC50 |
0.4 μM
Compound: SL44
|
Antiproliferative activity against human HCCLM3 cells overexpressing HsClpP assessed as inhibition of cell growth (Rvb = 2.5 +/- 0.1 microM)
Antiproliferative activity against human HCCLM3 cells overexpressing HsClpP assessed as inhibition of cell growth (Rvb = 2.5 +/- 0.1 microM)
|
[PMID: 38905539] |
| HCCLM3 | IC50 |
19.1 μM
Compound: SL44
|
Antiproliferative activity against human HCCLM3 cells harboring HsClpP knockdown assessed as inhibition of cell growth (Rvb = 2.5 +/- 0.1 microM)
Antiproliferative activity against human HCCLM3 cells harboring HsClpP knockdown assessed as inhibition of cell growth (Rvb = 2.5 +/- 0.1 microM)
|
[PMID: 38905539] |
| HCCLM3 | IC50 |
3.1 μM
Compound: SL44
|
Antiproliferative activity against human HCCLM3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human HCCLM3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
|
[PMID: 38905539] |
| HepG2 | IC50 |
0.9 μM
Compound: SL44
|
Antiproliferative activity against human HepG2 cells overexpressing HsClpP assessed as inhibition of cell growth (Rvb = 3.5 +/- 0.1 microM)
Antiproliferative activity against human HepG2 cells overexpressing HsClpP assessed as inhibition of cell growth (Rvb = 3.5 +/- 0.1 microM)
|
[PMID: 38905539] |
| HepG2 | IC50 |
10.1 μM
Compound: SL44
|
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
|
[PMID: 38905539] |
| HepG2 | IC50 |
18.5 μM
Compound: SL44
|
Antiproliferative activity against human HepG2 cells harboring HsClpP knockdown assessed as inhibition of cell growth (Rvb = 3.5 +/- 0.1 microM)
Antiproliferative activity against human HepG2 cells harboring HsClpP knockdown assessed as inhibition of cell growth (Rvb = 3.5 +/- 0.1 microM)
|
[PMID: 38905539] |
Chemical Information
-
CAS No. 3054715-45-3
-
Appearance Solid
-
Molecular Weight 410.87
-
Formula C22H20ClFN4O
-
Color White to off-white
-
SMILES
ClC1=C(F)C=CC(CC2=NOC(C3CCN(CC4=CC=CC(C#N)=C4)CC3)=N2)=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 70 mg/mL (170.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (266 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4339 mL | 12.1693 mL | 24.3386 mL | 60.8465 mL |
| 5 mM | 0.4868 mL | 2.4339 mL | 4.8677 mL | 12.1693 mL | |
| 10 mM | 0.2434 mL | 1.2169 mL | 2.4339 mL | 6.0846 mL | |
| 15 mM | 0.1623 mL | 0.8113 mL | 1.6226 mL | 4.0564 mL | |
| 20 mM | 0.1217 mL | 0.6085 mL | 1.2169 mL | 3.0423 mL | |
| 25 mM | 0.0974 mL | 0.4868 mL | 0.9735 mL | 2.4339 mL | |
| 30 mM | 0.0811 mL | 0.4056 mL | 0.8113 mL | 2.0282 mL | |
| 40 mM | 0.0608 mL | 0.3042 mL | 0.6085 mL | 1.5212 mL | |
| 50 mM | 0.0487 mL | 0.2434 mL | 0.4868 mL | 1.2169 mL | |
| 60 mM | 0.0406 mL | 0.2028 mL | 0.4056 mL | 1.0141 mL | |
| 80 mM | 0.0304 mL | 0.1521 mL | 0.3042 mL | 0.7606 mL | |
| 100 mM | 0.0243 mL | 0.1217 mL | 0.2434 mL | 0.6085 mL |
SL44 Related Classifications
HY-162650 Related Classifications
Powered by Bioz