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Cat. No.: HY-N8540

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Ilicicolin H

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Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC₅₀ = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC₅₀ = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with K_D of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection.

For research use only. We do not sell to patients.

Purity: 96.7%
CAS No.: 12689-26-8
Formula: C₂₇H₃₁NO₄
Molecular Weight:433.54

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Ilicicolin H Chemical Structure

CAS No.: 12689-26-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PGK1

9.02 μM (IC₅₀)

All Phosphoglycerate Kinase (PGK) Isoforms :

PGK1

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	13.84 μM Compound: 10	Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38527379]
A549	IC₅₀	7.01 μM Compound: 10	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38527379]
B16-F10	IC₅₀	21.58 μM Compound: 10	Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38527379]
CT26	IC₅₀	19.54 μM Compound: 10	Cytotoxicity against mouse CT26 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against mouse CT26 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38527379]
HCT-116	IC₅₀	10.75 μM Compound: 10	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38527379]
MC-38	IC₅₀	19.55 μM Compound: 10	Cytotoxicity against mouse MC38 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against mouse MC38 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38527379]
MDA-MB-231	IC₅₀	9.98 μM Compound: 10	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38527379]
MDA-MB-435	IC₅₀	6.34 μM Compound: 10	Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38527379]
NCI-H1703	IC₅₀	6.65 μM Compound: 10	Cytotoxicity against human NCI-H1703 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human NCI-H1703 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38527379]
PC-3	IC₅₀	>50 μM Compound: 10	Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38527379]
SNB-19	IC₅₀	14.59 μM Compound: 10	Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38527379]

In Vitro

Ilicicolin H (1-8 μM, 24 h) induces apoptosis and increases active cleaved fragments of Caspase-3, Caspase-9 levels in HepG2 and Huh7 cells^[1].
Ilicicolin H (2-8 μM, 6 h) reduces the levels of HIF-1α induced by CoCl₂ and the phosphorylation levels of PDHK1 at T338 induced by EGF in HepG2 cells^[1].
Ilicicolin H (1-8 μM, 6 h) inhibits lactate production and glucose uptake in HepG2 cells^[1].
Ilicicolin H shows anti-fungal activity against C. albicans (0.04 to 0.31 μg/mL), other Candida species (0.01 to 5.0 μg/mL), Cryptococcus (MIC = 0.1-1.56 μg/mL) and A. fumigatus (MIC = 0.08 μg/mL)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

HepG2 and Huh7 cells
Concentration:

1, 2, 4 and 8 μM
Incubation Time:

24 h
Result:

Increased C-Cas3, C-Cas9, and C-Parp levels.
Increased apoptotic cells.

In Vivo

Ilicicolin H (6.25-50 mg/kg, p.o., daily for 2 days) reduces C. albicans burden in C. albicans infected mice models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C. albicans infected mice models^[2]
Dosage:

6.25, 12.5, 25 and 50 mg/kg
Administration:

Orally administration, daily for 2 days
Result:

Reduced C. albicans burden.

Chemical Information

CAS No. 12689-26-8
Appearance Solid
Molecular Weight 433.54
Formula C₂₇H₃₁NO₄
Color Light yellow to yellow
SMILES

O=C1C(C([C@H]2[C@H](/C=C/C)[C@@]3([H])C[C@@H](C)CC[C@]3([H])C(C)=C2)=O)=C(O)C(C4=CC=C(O)C=C4)=CN1
Structure Classification
- Others
Initial Source
- Microorganisms
Campylocarpon sp.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li M, et al. A novel inhibitor of PGK1 suppresses the aerobic glycolysis and proliferation of hepatocellular carcinoma. Biomed Pharmacother. 2023 Feb;158:114115. [Content Brief]

[2]. Singh SB, et al. Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h. ACS Med Chem Lett. 2012 Sep 7;3(10):814-7. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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