Butabindide oxalate
Based on 2 publication(s) in Google Scholar
Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.98%
- CAS 番号: 185213-03-0
- 分子式: C19H27N3O6
- 分子量:393.43
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Butabindide oxalate
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生物活性
製品説明
IC50 & Target
IC50: 7 nM (TPP II) and 10 μM (TPP I)[1]
体外実験
Butabindide (UCL-1397; 0-24 nM; membranes of rat cerebral cortex) oxalate inhibits TPP II activity of cerebral membranes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice (25-30 g)[2]
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Dosage:10 mg/kg
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Administration:Intravenous injection; for 20 minutes
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Result:Reduces food intake and elicits other behavioral concomitants of satiation.
化学情報
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CAS 番号 185213-03-0
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性状 Solid
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分子量 393.43
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分子式 C19H27N3O6
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Color White to off-white
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SMILES
O=C([C@H]1N(C([C@@H](N)CC)=O)C2=C(C=CC=C2)C1)NCCCC.O=C(O)C(O)=O
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別名
UCL-1397 oxalate
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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J Biol Chem
Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding. [Abstract]2018 Dec 7;293(49):18864-18878. PMID: 30291141 -
溶剤 & 溶解度
体外:
H2O : 39 mg/mL (99.13 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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CCK-8/WST-8 Cell Proliferation Assay
The CCK-8/WST-8 assay is based on the reduction of the water-soluble tetrazolium salt WST-8 to a water-soluble formazan product by cellular dehydrogenases in metabolically active cells, where the generated formazan amount is proportional to the number of living cells and is quantified by measuring absorbance in the visible range, providing a colorimetric readout for cell viability and proliferation assessment. This class of tetrazolium-based assays improves upon earlier MTT-based systems by producing a water-soluble formazan, eliminating the need for organic solubilization steps and enabling direct spectrophotometric measurement in culture medium.
純度とドキュメンテーション
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データシート (277 KB)
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SDS (394 KB)
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- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Ganellin CR, et, al. Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. J Med Chem. 2005 Nov 17;48(23):7333-42. [Content Brief]
[2]. Rose C, et, al. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature. 1996 Apr 4;380(6573):403-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.5417 mL | 12.7087 mL | 25.4175 mL | 63.5437 mL |
| 5 mM | 0.5083 mL | 2.5417 mL | 5.0835 mL | 12.7087 mL | |
| 10 mM | 0.2542 mL | 1.2709 mL | 2.5417 mL | 6.3544 mL | |
| 15 mM | 0.1694 mL | 0.8472 mL | 1.6945 mL | 4.2362 mL | |
| 20 mM | 0.1271 mL | 0.6354 mL | 1.2709 mL | 3.1772 mL | |
| 25 mM | 0.1017 mL | 0.5083 mL | 1.0167 mL | 2.5417 mL | |
| 30 mM | 0.0847 mL | 0.4236 mL | 0.8472 mL | 2.1181 mL | |
| 40 mM | 0.0635 mL | 0.3177 mL | 0.6354 mL | 1.5886 mL | |
| 50 mM | 0.0508 mL | 0.2542 mL | 0.5083 mL | 1.2709 mL | |
| 60 mM | 0.0424 mL | 0.2118 mL | 0.4236 mL | 1.0591 mL | |
| 80 mM | 0.0318 mL | 0.1589 mL | 0.3177 mL | 0.7943 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Butabindide oxalate 関連分類
HY-107759 関連分類
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