185213-03-0
185213-03-0
Chemical Structure
Butabindide oxalate
Synonym(s): UCL-1397 oxalate
- CAS No.: 185213-03-0
- Formula:C19H27N3O6
- Molecular Weight:393.43
IUPAC Name: (S)-1-((S)-2-aminobutanoyl)-N-butylindoline-2-carboxamide oxalate
InChIKey: KKMJFDVOXSGHBF-SLHAJLBXSA-N
SMILES: O=C([C@H]1N(C([C@@H](N)CC)=O)C2=C(C=CC=C2)C1)NCCCC.O=C(O)C(O)=O
Biological Activity: Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Butabindide oxalate | 98.98% | Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation. | ||||||||||||||||||||
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References
- [1]. Ganellin CR, et, al. Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. J Med Chem. 2005 Nov 17;48(23):7333-42. [Content Brief]
- [2]. Rose C, et, al. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature. 1996 Apr 4;380(6573):403-9. [Content Brief]
Keywords
