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Butabindide (Synonyms: UCL-1397)

Cat. No.: HY-150070
Handling Instructions

Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation.

For research use only. We do not sell to patients.

Butabindide Chemical Structure

Butabindide Chemical Structure

CAS No. : 175553-48-7

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Description

Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation[1][2].

IC50 & Target

IC50: 7 nM (TPP II) and 10 μM (TPP I)[1]

In Vitro

Butabindide (UCL-1397; 0-24 nM; membranes of rat cerebral cortex) inhibits TPP II activity of cerebral membranes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Butabindide (UCL-1397; 10 mg/kg; i.v.; for 20 min) inhibits the breakdown of CCK-8 in the gastrointestinal tract and increases satiety in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (25-30 g)
Dosage: 10 mg/kg
Administration: Intravenous injection; for 20 minutes
Result: Reduces food intake and elicits other behavioral concomitants of satiation.
Molecular Weight

303.40

Formula

C17H25N3O2

CAS No.
SMILES

CC[[email protected]](N)C(N1C2=CC=CC=C2C[[email protected]]1C(NCCCC)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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References
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Butabindide
Cat. No.:
HY-150070
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