175553-48-7
175553-48-7
Chemical Structure
Butabindide
Synonym(s): UCL-1397
- CAS No.: 175553-48-7
- Formula:C17H25N3O2
- Molecular Weight:303.40
IUPAC Name: (S)-1-((S)-2-aminobutanoyl)-N-butylindoline-2-carboxamide
InChIKey: HAQIRIMIVLFYIX-ZFWWWQNUSA-N
SMILES: CC[C@H](N)C(N1C2=CC=CC=C2C[C@H]1C(NCCCC)=O)=O
Biological Activity: Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation[1][2].
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Butabindide | Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation. | |||||||||||||||||||||
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References
- [1]. Ganellin CR, et, al. Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. J Med Chem. 2005 Nov 17;48(23):7333-42. [Content Brief]
- [2]. Rose C, et, al. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature. 1996 Apr 4;380(6573):403-9. [Content Brief]
Keywords
