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Cat. No.: HY-U00363A

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(rac)-CHEMBL333994

(Synonyms: (rac)-FK-480)

(rac)-CHEMBL333994 is the racemate of CHEMBL333994 (HY-U00363). CHEMBL333994 is a potent and orally active Cholecystokinin A receptor (CCK-A receptor) antagonist, with an IC₅₀ of 0.67 nM. CHEMBL333994 selectively antagonizes peripheral CCK receptors. CHEMBL333994 increases CCK mRNA level. CHEMBL333994 can be used for research of chronic pancreatitis.

For research use only. We do not sell to patients.

CAS No.: 126149-42-6
Formula: C₂₆H₁₉FN₄O₂
Molecular Weight:438.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

(rac)-CHEMBL333994 Chemical Structure

CAS No.: 126149-42-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Cholecystokinin Receptor Isoforms :

CCKAR
CCKBR

Chemical Information

CAS No. 126149-42-6
Molecular Weight 438.45
Formula C₂₆H₁₉FN₄O₂
SMILES

O=C(C(N1)=CC2=C1C=CC=C2)NC3C(N4C5=C(CC4)C=CC=C5C(C6=CC=CC=C6F)=N3)=O
Synonyms

(rac)-FK-480
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Satoh Y, et al. Studies on a novel, potent and orally effective cholecystokinin A antagonist, FK-480. Synthesis and structure-activity relationships of FK-480 and related compounds. Chem Pharm Bull (Tokyo). 1994 Oct;42(10):2071-83. [Content Brief]

[2]. Funakoshi A,et al. Effect of a new cholecystokinin antagonist (FK 480) on gene expression of cholecystokinin and secretin in rat intestine. J Gastroenterol. 1994 Jun;29(3):385-7. [Content Brief]

[3]. Moriyoshi Y, et al. Duration of anti-cholecystokinin (CCK) action on the rat exocrine pancreas of new CCK receptor antagonist FK480 administered orally. J Gastroenterol. 1996 Apr;31(2):249-53 [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
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References

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(rac)-CHEMBL333994

All Cholecystokinin Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(rac)-CHEMBL333994 Related Classifications

HY-U00363A Related Classifications