Cat. No.: HY-P2932

Cholecystokinin

Name: Cholecystokinin
Brand: MedChemExpress
SKU: HY-P2932
Price: 750.00 USD
Availability: InStock
Rating: 5 (2 reviews)

(Synonyms: Cholecystokinin-33(human); CCK-33(human))

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Cholecystokinin (Cholecystokinin-33 (human); CCK-33 (human)) is a secreted peptide hormone. Cholecystokinin activates CCK-A receptors to reduce food intake and induce satiety, and activates CCK1 receptors to mediate insulin release. Cholecystokinin mediates anti-inflammatory and renoprotective effects on diabetic kidney macrophages through CCK-1 receptors, and limits diabetic kidney injury through CCK-2 receptors. Cholecystokinin can be used in research on diabetic nephropathy and obesity.

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Pureté : 98.85%
CAS No.: 9011-97-6
Formule: C₁₆₇H₂₆₃N₅₁O₅₂S₄
Masse moléculaire:3945.45

Stockage:

Sealed storage, away from moisture and light.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Cholecystokinin Chemical Structure

CAS No.: 9011-97-6

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- Essai clinique
Chemical Information
Publications (2)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9]

CCK-A

Voir tous les produits spécifiques à Isoform Cholecystokinin Receptor :

CCKAR
CCKBR

In Vitro

Cholecystokinin exhibits 89.5% binding in the cell-free OAL-656 radioimmunoassay^[1].
Cholecystokinin ELISA antiserum shows a cross-reactivity of 42.9% with CCK-33 (human)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Chemical Information

CAS No. 9011-97-6
Appearance Solid
Masse moléculaire 3945.45
Formule C₁₆₇H₂₆₃N₅₁O₅₂S₄
Color White to off-white
Synonyms

Cholecystokinin-33(human); CCK-33(human)
Sequence

Lys-Ala-Pro-Ser-Gly-Arg-Met-Ser-Ile-Val-Lys-Asn-Leu-Gln-Asn-Leu-Asp-Pro-Ser-His-Arg-Ile-Ser-Asp-Arg-Asp-{Tyr(SO3H)}-Met-Gly-Trp-Met-Asp-Phe-NH2
Sequence Shortening

KAPSGRMSIVKNLQNLDPSHRISDRD-{Tyr(SO3H)}-MGWMDF-NH2
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (2)

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Adv Sci (Weinh)

Nanomedicine Penetrating Blood-Pancreas Barrier for Effective Treatment of Acute Pancreatitis. [Abstract]

2025 Apr;12(13):e2413925. PMID: 39950925
SSRN

2026 Jun 16.

Solvant et solubilité

In Vitro:

DMSO : 12.5 mg/mL (3.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.2535 mL

1.2673 mL

2.5346 mL

5 mM

---

10 mM

---

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Meier R, et al. Effect of loxiglumide, a cholecystokinin antagonist, on pancreatic polypeptide release in humans. Gastroenterology. 1990 Dec;99(6):1757-62.

[2]. Weller A, et al. Endogenous cholecystokinin reduces feeding in young rats. Science (New York, N.Y.). 1990 Mar 30;247(4950):1589-91.

[3]. Smith GP, et al. Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat. Science (New York, N.Y.). 1981 Aug 28;213(4511):1036-7. [Content Brief]

[4]. Song WY, et al. (−)-Epigallocatechin-3-gallate induces secretion of anorexigenic gut hormones. Journal of Clinical Biochemistry and Nutrition. 2015;57(2):164-9.

[5]. Zabielski R, et al. Bovine pancreatic secretion in the first week of life: potential involvement of intestinal CCK receptors. Regulatory peptides. 2002 Feb 15;103(2-3):93-104.

[6]. Lo CM, et al. Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice. Diabetes. 2011 Jul;60(7):2000-7.

[7]. Miyamoto S, et al. Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage: anti-inflammatory effect of cholecystokinin. Diabetes. 2012 Apr 1;61(4):897-907.

[8]. Lo CM, et al. Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity. Gastroenterology. 2010 May;138(5):1997-2005.

[9]. KAPICA M, et al. 1 Department of Biochemistry and Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Poland; 2 The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Science, Jablonna, Poland; 3 Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland; 4 Department of Physiology and Pathophysiology, Faculty of Pharmacy Medical University of Warsaw, Warsaw, Poland, 5 Department of Physiology ....

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.2535 mL	1.2673 mL	2.5346 mL	6.3364 mL

Bioz

Keywords

Cholecystokinin

2 Cited Publications

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Cholecystokinin

Publications Citing Use of MedChemExpress (MCE) Cholecystokinin

Voir tous les produits spécifiques à Isoform Cholecystokinin Receptor