1. Epigenetics
  2. Histone Methyltransferase

AMI-1 

Cat. No.: HY-18962 Purity: 99.36%
Data Sheet SDS Handling Instructions

AMI-1 is a potent, cell-permeable compound which inhibits protein arginine N-methyltransferases (PRMTs), including human PRMT1 (IC50 = 8.8μM) and yeast-Hmt1p (IC50 = 3.0μM), by blocking peptide-substrate binding.

For research use only. We do not sell to patients.
AMI-1 Chemical Structure

AMI-1 Chemical Structure

CAS No. : 20324-87-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO $90 In-stock
5 mg $75 In-stock
10 mg $120 In-stock
25 mg $240 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

AMI-1 is a potent, cell-permeable compound which inhibits protein arginine N-methyltransferases (PRMTs), including human PRMT1 (IC50 = 8.8μM) and yeast-Hmt1p (IC50 = 3.0μM), by blocking peptide-substrate binding. IC50 value: 8.8μM (human PRMT1), 3.0μM (yeast-Hmt1p) Target: human PRMT1, yeast-Hmt1p in vitro: AMI-1 suppresses the transcriptional coactivator activity of PRMT1 and PRMT4 and it inhibits HIV-1 RT polymerase (IC50 = 5.0μM). PRMT1 methylates histone H4, and is essential for other subsequent histone modifications.[1] AMI-1 is the most active nonpeptidic inhibitor reported to be selective against PRMT1. AMI-1 is a selective PRMT inhibitor with a bisanionic structure that is related to compounds known to generate pleiotropic interactions with many proteins, should be further optimized before exploring additional binding pockets. [2] in vivo: AMI-1 is administered intranasally to chronic AIPI rats to determine PRMT effects on asthmatic parameters. AMI-1 inhibited the expression of COX2 in TGF-β-stimulated cells. AMI-1 administered to AIPI rats reduced COX2 production and humoral immune response, and it abrogated mucus secretion and collagen generation.[1]

References
M.Wt

548.45

Formula

C₂₁H₁₄N₂Na₂O₉S₂

CAS No.

20324-87-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 46 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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AMI-1
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