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CHTOP - chromatin target of PRMT1 Gene

Also Known as FOP; SRAG; SRAG-3; SRAG-5; pp7704; C1orf77; FL-SRAG; C10orf77

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26097

About CHTOP

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,634,066-153,646,306 (from NCBI)

This gene has 7 transcripts (splice variants), 261 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 21.4), spleen (RPKM 20.4) and 25 other tissues.

Summary

This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2015]

CHTOP Products (4)

mRNA	Protein	Name
NM_001206612.2	NP_001193541.1	chromatin target of PRMT1 protein isoform 2
NM_001244664.2	NP_001231593.1	chromatin target of PRMT1 protein isoform 3
NM_001317077.2	NP_001304006.1	chromatin target of PRMT1 protein isoform 4
NM_015607.4	NP_056422.2	chromatin target of PRMT1 protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables methyl-CpG binding	IDA IDA: Inferred from direct assay	25284789	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14667819	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	25284789	GOA
involved in mRNA export from nucleus	IDA IDA: Inferred from direct assay	23299939	GOA
involved in positive regulation of ATP-dependent activity	IDA IDA: Inferred from direct assay	23299939	GOA
involved in positive regulation of helicase activity	IDA IDA: Inferred from direct assay	23299939	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nuclear speck	IDA IDA: Inferred from direct assay	23299939	GOA
part of transcription export complex	IDA IDA: Inferred from direct assay	23299939	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHTOP Protein Structure

FoP_duplication

0
100
200
248 a.a.

Protein Preferred Names	Protein Names
chromatin target of PRMT1 protein	friend of PRMT1 protein

CHTOP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CHTOP	Q9Y3Y2	ALYREF	Homo sapiens	Q86V81	Anti Tag CoIP	23299939
Intra	CHTOP	Q9Y3Y2	ALYREF	Homo sapiens	Q86V81	Pull Down	23299939
Intra	CHTOP	Q9Y3Y2	ALYREF	Homo sapiens	Q86V81	Anti Bait CoIP	23299939
Intra	CHTOP	Q9Y3Y2	DDX39B	Homo sapiens	Q13838	Anti Bait CoIP	23299939
Intra	CHTOP	Q9Y3Y2	DDX39B	Homo sapiens	Q13838	Anti Tag CoIP	23299939
Intra	CHTOP	Q9Y3Y2	DDX39B	Homo sapiens	Q13838	Anti Tag CoIP	33961781
Intra	CHTOP	Q9Y3Y2	DDX39B	Homo sapiens	Q13838	Pull Down	23299939
Intra	CHTOP	Q9Y3Y2	SMN1	Homo sapiens	Q16637	Y2H Prey Pooling	25416956
Intra	CHTOP	Q9Y3Y2	SMN1	Homo sapiens	Q16637	Validated Y2H	25416956
Intra	CHTOP	Q9Y3Y2	SMN1	Homo sapiens	Q16637	Y2H Array	25416956
Intra	CHTOP	Q9Y3Y2	NXF1	Homo sapiens	Q9UBU9	Anti Tag CoIP	23299939
Intra	CHTOP	Q9Y3Y2	NXF1	Homo sapiens	Q9UBU9	Pull Down	23299939
Intra	CHTOP	Q9Y3Y2	ERH	Homo sapiens	P84090	Y2H Array	25416956
Intra	CHTOP	Q9Y3Y2	ERH	Homo sapiens	P84090	Anti Tag CoIP	33961781
Intra	CHTOP	Q9Y3Y2	ERH	Homo sapiens	P84090	Y2H Prey Pooling	25416956
Intra	CHTOP	Q9Y3Y2	ERH	Homo sapiens	P84090	Crosslink	30021884
Intra	CHTOP	Q9Y3Y2	KHDRBS2	Homo sapiens	Q5VWX1	Validated Y2H	25416956
Intra	CHTOP	Q9Y3Y2	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	25416956
Intra	CHTOP	Q9Y3Y2	PRMT1	Homo sapiens	Q99873	Anti Tag CoIP	33961781
Intra	CHTOP	Q9Y3Y2	PRMT1	Homo sapiens	Q99873	Anti Bait CoIP	19858291

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Autosomal Dominant Beta Thalassemia	Inclusion Body Beta-Thalassemia
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Farmer'S Lung	Farmer Lung Farmers Lung Farmer'S Lung Disease Farmers' Lung Farmers' Lung Disease Mouldy Hay Disease Moldy Hay Disorder Fibrosis Of Lung With Farmers' Lung Harvesters' Hypersensitivity Pneumonitis Moldy Hay Pneumoconiosis Haymakers' Hypersensitivity Pneumonitis Threshers' Lung Harvester Lung Haymaker Lung

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02697	CHTOP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22441	Chtop Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CHTOP	VGNC	VGNC:53336
Bos taurus	CHTOP	VGNC	VGNC:27353
Macaca mulatta	CHTOP	VGNC	VGNC:71090
Mus musculus	CHTOP	MGD	MGI:1913761
Rattus norvegicus	CHTOP	RGD	RGD:1359407
Felis catus	CHTOP	VGNC	VGNC:107858
Others	CHTOP	NCBI