1. Epigenetics
  2. Histone Methyltransferase
  3. MS023 dihydrochloride

MS023 dihydrochloride 

Cat. No.: HY-19615B Purity: 99.49%
Handling Instructions

MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively.

For research use only. We do not sell to patients.

MS023 dihydrochloride Chemical Structure

MS023 dihydrochloride Chemical Structure

CAS No. : 1992047-64-9

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MS023 dihydrochloride:

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Description

MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1].

IC50 & Target

IC50: 30 nM (PRMT1), 119 nM (PRMT3), 83 nM (PRMT4), 4 nM (PRMT6), 5 nM (PRMT8)[1]

In Vitro

MS023 (1-1000 nM; 48 hours) inhibits PRMT1 methyltransferase activity in MCF7 cells[1].
MS023(1-1000 nM; 20 hours) inhibits PRMT6 methyltransferase activity in HEK293 cells[1].

Western Blot Analysis[1]

Cell Line: MCF7 and HEK293 cells
Concentration: 1.4, 4, 12, 37, 111, 333, and 1000 nM
Incubation Time: 48 hours for MCF7 cells; 20 hours for HEK293 cells
Result: Treatment potently and concentration-dependently reduced cellular levels of H4R3me2a (IC50=9±0.2 nM).
Treatment concentration-dependently reduced the H3R2me2a mark (IC50=56±7 nM).
Molecular Weight

360.32

Formula

C₁₇H₂₇Cl₂N₃O

CAS No.

1992047-64-9

SMILES

CC(OC1=CC=C(C=C1)C2=CNC=C2CN(C)CCN)C.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under argon

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under argon)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (416.30 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7753 mL 13.8766 mL 27.7531 mL
5 mM 0.5551 mL 2.7753 mL 5.5506 mL
10 mM 0.2775 mL 1.3877 mL 2.7753 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

MS023MS 023MS-023Histone MethyltransferaseInhibitorinhibitorinhibit

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MS023 dihydrochloride
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