MS023 dihydrochloride
Based on 24 publication(s) in Google Scholar
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.68%
- CAS. Nr.: 1992047-64-9
- Formel: C17H27Cl2N3O
- Molecular Weight:360.32
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Speicherung:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) MS023 dihydrochloride
More- Nat Commun. 2026 Feb 12;17(1):1214. [Abstract]
- Nat Commun. 2025 Jan 22;16(1):949. [Abstract]
- Nat Commun. 2025 Jan 2;16(1):87. [Abstract]
- Nucleic Acids Res. 2026 Jun 22;54(12):gkag655. [Abstract]
- Acta Pharm Sin B. 2022 Apr;12(4):1840-1855. [Abstract]
- Cell Rep Med. 2026 Jan 20;7(1):102542. [Abstract]
- Sci Adv. 2026 Jan 23;12(4):eaea3960. [Abstract]
- Cell Commun Signal. 2025 Mar 8;23(1):126. [Abstract]
- Acta Pharmacol Sin. 2022 Feb;43(2):457-469. [Abstract]
- Int J Biol Macromol. 2024 Oct;277(Pt 3):134411. [Abstract]
- Cell Rep. 2024 Jul 24;43(8):114537. [Abstract]
- Cell Rep. 2021 Sep 21;36(12):109731. [Abstract]
- J Med Chem. 2025 Feb 27;68(4):4373-4381. [Abstract]
- Eur J Med Chem. 2025 Dec 15:300:118123. [Abstract]
- Cell Mol Life Sci. 2025 Apr 7;82(1):142. [Abstract]
- EMBO Rep. 2025 Oct 20. [Abstract]
- EMBO Rep. 2025 Oct 6. [Abstract]
- Oncogenesis. 2022 Aug 8;11(1):45. [Abstract]
- Cancer. 2024 Apr 15;130(S8):1415-1423. [Abstract]
- Neurochem Int. 2024 Jun:176:105728. [Abstract]
- Bone. 2023 Nov:176:116887. [Abstract]
- J Proteome Res. 2024 Mar 1;23(3):1014-1027. [Abstract]
- PLoS One. 2023 Dec 22;18(12):e0296291. [Abstract]
- bioRxiv. 2026 May 29.
Customer Validation & Images
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Cell Proliferation/Viability Assay
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RT-PCR
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Cell Imaging/Staining
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IP
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WB
Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
IC50 & Target
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PRMT1 |
PRMT3 |
PRMT6 |
PRMT8 |
In Vitro
MS023 (1-1000 nM; 48 hours) inhibits PRMT1 methyltransferase activity in MCF7 cells[1].
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MS023(1-1000 nM; 20 hours) inhibits PRMT6 methyltransferase activity in HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:MCF7 and HEK293 cells
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Concentration:1.4, 4, 12, 37, 111, 333, and 1000 nM
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Incubation Time:48 hours for MCF7 cells; 20 hours for HEK293 cells
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Result:Treatment potently and concentration-dependently reduced cellular levels of H4R3me2a (IC50=9±0.2 nM).
Treatment concentration-dependently reduced the H3R2me2a mark (IC50=56±7 nM).
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD-scid IL2Rgnull (NSG) mice bearing primary MLL-r ALL cells[2]
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Dosage:160 mg/kg
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Administration:Intraperitoneal injection; PKC412 (100 mg/kg, i.g.), MS023 (160 mg/kg, i.p), or a combination for 4 weeks
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Result:Combinatorial treatment extended survival of leukemic mice relative to single treatments.
Chemical Information
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CAS. Nr. 1992047-64-9
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Appearance Solid
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Molecular Weight 360.32
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Formel C17H27Cl2N3O
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Color Gray to gray purple
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SMILES
CC(OC1=CC=C(C=C1)C2=CNC=C2CN(C)CCN)C.Cl.Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (24)
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Journal Impact Factor
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Most Recent
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Nat Commun
Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]2026 Feb 12;17(1):1214. PMID: 41680175 -
Nat Commun
2025 Jan 22;16(1):949. PMID: 39843447
MS023 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 22;16(1):949. [Abstract]
Representative images of FRAP of MSX1-mEGFP- expressing HEK293T treated with DMSO or MS023.
MS023 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 22;16(1):949. [Abstract]
Representative western blot images of Co-IP assays assessing the aDMA of MSX1 in treated with MS023 or PRMT1 siRNA.
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Nat Commun
Positive feedback between arginine methylation of YAP and methionine transporter SLC43A2 drives anticancer drug resistance. [Abstract]2025 Jan 2;16(1):87. PMID: 39747898 -
Nucleic Acids Res
RECQ4 arginine methylation suppresses single-stranded DNA gap accumulation at replication forks. [Abstract]2026 Jun 22;54(12):gkag655. PMID: 42363758 -
Acta Pharm Sin B
2022 Apr;12(4):1840-1855. PMID: 35847488 -
Cell Rep Med
2026 Jan 20;7(1):102542. PMID: 41564858
MS023 dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2026 Jan 20;7(1):102542. [Abstract]
The drug response curve and IC50 value for PRMT inhibitor MS023 and GSK591 combinations after U2AF2 knockdown in THP1 leukemia cells. Cell viability was assessed using a CCK8 assay.
MS023 dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2026 Jan 20;7(1):102542. [Abstract]
RT-PCR results detecting aberrantly spliced transcripts in THP1 leukemia cells, which were treated with PRMT inhibitor MS023 or GSK591 with or without U2AF2 knockdown.
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Sci Adv
TDRD3, a Tudor domain-containing protein, regulates Klf2-dependent Treg differentiation and function to modulate immune tolerance. [Abstract]2026 Jan 23;12(4):eaea3960. PMID: 41576154 -
Cell Commun Signal
2025 Mar 8;23(1):126. PMID: 40057764
MS023 dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Mar 8;23(1):126. [Abstract]
Immunoprecipitation and western blot analysis of arginine dimethylation in METTL14 overexpressed in HEK293T cells. Cells were treated with 1 μM EPZ015666, 1 μM MS023, or DMSO for 72 h and METTL14 is immunoprecipitated by anti-METTL14 antibody.
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Acta Pharmacol Sin
2022 Feb;43(2):457-469. PMID: 33850273 -
Int J Biol Macromol
PRMT1 and TDRD3 promote stress granule assembly by rebuilding the protein-RNA interaction network. [Abstract]2024 Oct;277(Pt 3):134411. PMID: 39097054 -
Cell Rep
Arginine methylation-enabled FUS phase separation with SMN contributes to neuronal granule formation. [Abstract]2024 Jul 24;43(8):114537. PMID: 39052476 -
Cell Rep
The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation. [Abstract]2021 Sep 21;36(12):109731. PMID: 34551290 -
J Med Chem
Opto-Epigenetic Regulation of Histone Arginine Asymmetric Dimethylation via Type I Protein Arginine Methyltransferase Inhibition. [Abstract]2025 Feb 27;68(4):4373-4381. PMID: 39961800 -
Eur J Med Chem
Discovery of novel indazole derivatives as type Ⅰ PRMTs inhibitors for the treatment of triple-negative breast cancer. [Abstract]2025 Dec 15:300:118123. PMID: 40929806 -
Cell Mol Life Sci
Dietary advanced glycation end-products exacerbate sarcopenia onset by activating apoptosis through PRMT1-mediated CRTC3 arginine methylation. [Abstract]2025 Apr 7;82(1):142. PMID: 40192801 -
EMBO Rep
Tudor-based proteomic strategy pan-specifically enriches and identifies protein arginine methylation. [Abstract]2025 Oct 20. PMID: 41116072 -
EMBO Rep
2025 Oct 6. PMID: 41053315 -
Oncogenesis
Methylation of HBP1 by PRMT1 promotes tumor progression by regulating actin cytoskeleton remodeling. [Abstract]2022 Aug 8;11(1):45. PMID: 35941115 -
Cancer
Type-I protein arginine methyltransferase inhibition primes anti-programmed cell death protein 1 immunotherapy in triple-negative breast cancer. [Abstract]2024 Apr 15;130(S8):1415-1423. PMID: 38079306 -
Neurochem Int
The antidepressant effects of protein arginine methyltransferase 2 involve neuroinflammation. [Abstract]2024 Jun:176:105728. PMID: 38561150 -
Bone
PRMT1-mediated arginine methylation promotes postnatal calvaria bone formation through BMP-Smad signaling. [Abstract]2023 Nov:176:116887. PMID: 37634683 -
J Proteome Res
ETD-Based Proteomic Profiling Improves Arginine Methylation Identification and Reveals Novel PRMT5 Substrates. [Abstract]2024 Mar 1;23(3):1014-1027. PMID: 38272855 -
PLoS One
Asymmetric and symmetric protein arginine methylation in methionine-addicted human cancer cells. [Abstract]2023 Dec 22;18(12):e0296291. PMID: 38134182 -
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : ≥ 150 mg/mL (416.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 33.33 mg/mL (92.50 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (69.38 mM); Clear solution; Need ultrasonic and warming
Reinheit & Dokumentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81. [Content Brief]
[2]. Yinghui Zhu, et al. Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. Blood. 2019 Oct 10;134(15):1257-1268. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.7753 mL | 13.8766 mL | 27.7531 mL | 69.3828 mL |
| 5 mM | 0.5551 mL | 2.7753 mL | 5.5506 mL | 13.8766 mL | |
| 10 mM | 0.2775 mL | 1.3877 mL | 2.7753 mL | 6.9383 mL | |
| 15 mM | 0.1850 mL | 0.9251 mL | 1.8502 mL | 4.6255 mL | |
| 20 mM | 0.1388 mL | 0.6938 mL | 1.3877 mL | 3.4691 mL | |
| 25 mM | 0.1110 mL | 0.5551 mL | 1.1101 mL | 2.7753 mL | |
| 30 mM | 0.0925 mL | 0.4626 mL | 0.9251 mL | 2.3128 mL | |
| 40 mM | 0.0694 mL | 0.3469 mL | 0.6938 mL | 1.7346 mL | |
| 50 mM | 0.0555 mL | 0.2775 mL | 0.5551 mL | 1.3877 mL | |
| 60 mM | 0.0463 mL | 0.2313 mL | 0.4626 mL | 1.1564 mL | |
| 80 mM | 0.0347 mL | 0.1735 mL | 0.3469 mL | 0.8673 mL | |
| DMSO | 100 mM | 0.0278 mL | 0.1388 mL | 0.2775 mL | 0.6938 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
MS023 dihydrochloride Related Classifications
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