1. Epigenetics
  2. Histone Methyltransferase

MS023 

Cat. No.: HY-19615 Purity: 99.84%
Handling Instructions

MS023 is a potent, selective, and cell-active inhibitor of human type I PRMTs with IC50 of 4-119 nM.

For research use only. We do not sell to patients.

MS023 Chemical Structure

MS023 Chemical Structure

CAS No. : 1831110-54-3

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 152 In-stock
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2 mg USD 96 In-stock
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5 mg USD 132 In-stock
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10 mg USD 216 In-stock
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25 mg USD 396 In-stock
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50 mg USD 732 In-stock
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100 mg USD 1320 In-stock
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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

MS023 is a potent, selective, and cell-active inhibitor of human type I PRMTs with IC50 of 4-119 nM. IC50 value: 4-119 nM Target: type I PRMTs in vitro: MS023 potently inhibits PRMT1 (IC50 = 30 ± 9 nM), PRMT3 (IC50 = 119 ± 14 nM), PRMT4 (IC50 = 83 ± 10 nM), PRMT6 (IC50 = 4 ± 0.5 nM), and PRMT8 (IC50 = 5 ± 0.1 nM). Importantly, MS023 does not inhibit any type II PRMTs (PRMT5 and 9) and type III PRMT (PRMT7) at concentrations up to 10 μM. MS023 displays high potency for type I PRMTs including PRMT1, -3, -4, -6, and -8 but is completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. MS023 potently decreases cellular levels of histone arginine asymmetric dimethylation. It also reduces global levels of arginine asymmetric dimethylation and concurrently increased levels of arginine monomethylation and symmetric dimethylation in cells. [1]

Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (104.38 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4795 mL 17.3974 mL 34.7947 mL
5 mM 0.6959 mL 3.4795 mL 6.9589 mL
10 mM 0.3479 mL 1.7397 mL 3.4795 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

287.4

Formula

C₁₇H₂₅N₃O

CAS No.

1831110-54-3

SMILES

CN(CCN)CC1=CNC=C1C2=CC=C(OC(C)C)C=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
MS023
Cat. No.:
HY-19615
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MS023

Cat. No.: HY-19615