CM112
CM112 is a selective protein arginine methyltransferase 1 (PRMT1) degrader by tethering hydrophobic tag, adamantane, to MS023 with a 5-PEG linker. CM112 induces the degradation of PRMT1 in various solid cancer cell lines. CM112 can also target the nonenzymatic function of PRMT1 by downregulating the stability of the orphan receptor TR3. CM112 is promising for research of cancers.
For research use only. We do not sell to patients.
- Formula: C39H61N5O7
- Molecular Weight:711.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
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PRMT1 |
Chemical Information
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Molecular Weight 711.93
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Formula C39H61N5O7
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SMILES
O=C(CCOCCOCCOCCOCCOCCNC(CC12C[C@@H](C[C@H]3C2)C[C@@H](C3)C1)=O)NC4=CC=C(C5=CNC=C5CN(CCN)C)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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