NABP1 - nucleic acid binding protein 1 Gene

Also Known as SSB2; OBFC2A; SOSS-B2; NABP1-OT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64859

About NABP1

Cytogenetic location: 2q32.3 Genomic coordinates (GRCh38): 2:191,678,136-191,686,943 (from NCBI)

This gene has 16 transcripts (splice variants), 205 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in appendix (RPKM 17.5), spleen (RPKM 12.9) and 21 other tissues.

Summary

Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

NABP1 Products (2)

mRNA Protein Name
NM_001031716.5 NP_001026886.1 SOSS complex subunit B2 isoform 1
NM_001254736.3 NP_001241665.1 SOSS complex subunit B2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19683501 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
19683501 GOA
involved in DNA repair IMP
IMP: Inferred from mutant phenotype
19683501 GOA
involved in double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
19683501 GOA
involved in double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
19605351 GOA
involved in mitotic G2/M transition checkpoint IDA
IDA: Inferred from direct assay
19683501 GOA
involved in mitotic G2/M transition checkpoint IMP
IMP: Inferred from mutant phenotype
19683501 GOA
involved in response to ionizing radiation IMP
IMP: Inferred from mutant phenotype
19605351 GOA
Cellular Component GO Annotation Evidence References Source
part of SOSS complex IDA
IDA: Inferred from direct assay
18449195 GOA
part of SOSS complex IPI
IPI: Inferred from physical interaction
19683501 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19683501 GOA
located in site of double-strand break IDA
IDA: Inferred from direct assay
19683501 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NABP1 Protein Structure

tRNA_anti-codon

tRNA_anti-codon: OB-fold nucleic acid binding domain (31 - 88)

  • 0
  • 100
  • 204 a.a.
Protein Preferred Names Protein Names

SOSS complex subunit B2

  • NABP1 3'UTR overlapping transcript 1

NABP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NABP1 Q96AH0 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
NABP1 Q96AH0 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
NABP1 Q96AH0 MKRN3 Homo sapiens Q13064
Validated Y2H
25416956
Intra
NABP1 Q96AH0 INTS3 Homo sapiens Q68E01
Anti Bait CoIP
19683501
Intra
NABP1 Q96AH0 INTS3 Homo sapiens Q68E01
Pull Down
19683501
Intra
NABP1 Q96AH0 TRIM7 Homo sapiens Q9C029
Validated Y2H
32296183
Intra
NABP1 Q96AH0 TRIM7 Homo sapiens Q9C029
Y2H Prey Pooling
32296183
Intra
NABP1 Q96AH0 TRIM7 Homo sapiens Q9C029
Y2H Array
32296183
Intra
NABP1 Q96AH0 PURB Homo sapiens Q96QR8
Validated Y2H
32296183
Intra
NABP1 Q96AH0 PURB Homo sapiens Q96QR8
Y2H Array
32296183
Intra
NABP1 Q96AH0 PURB Homo sapiens Q96QR8
Y2H Prey Pooling
32296183
Intra
NABP1 Q96AH0 COPS3 Homo sapiens Q9UNS2
Validated Y2H
32296183
Intra
NABP1 Q96AH0 COPS3 Homo sapiens Q9UNS2
Y2H Prey Pooling
32296183
Intra
NABP1 Q96AH0 COPS3 Homo sapiens Q9UNS2
Y2H Array
32296183
Intra
NABP1 Q96AH0 TFCP2 Homo sapiens Q12800
Y2H Array
25416956
Intra
NABP1 Q96AH0 KHDRBS2 Homo sapiens Q5VWX1
Y2H Prey Pooling
25416956
Intra
NABP1 Q96AH0 RBMX Homo sapiens P38159
Y2H Array
25416956
Intra
NABP1 Q96AH0 RBMX Homo sapiens P38159
Y2H Array
32296183
Intra
NABP1 Q96AH0 RBMX Homo sapiens P38159
Y2H Prey Pooling
25416956
Intra
NABP1 Q96AH0 RBMX Homo sapiens P38159
Validated Y2H
25416956
Intra
NABP1 Q96AH0 RBMX Homo sapiens P38159
Y2H Prey Pooling
32296183
Intra
NABP1 Q96AH0 QKI Homo sapiens Q96PU8
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Cholestasis, Intrahepatic, Of Pregnancy 3

  • ICP3

  • Cholestasis, Intrahepatic, Of Pregnancy, 3

  • Intrahepatic Cholestasis Of Pregnancy 3

  • Pregnancy Related Cholestasis 3

  • Cholestasis Of Pregnancy, Intrahepatic 3

  • Cholestasis, Intrahepatic, Of Pregnancy, Type 3
Splenic Manifestation Of Leukemia

  • Splenic Leukemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08998 NABP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22667 Nabp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NABP1 RGD RGD:1306658
Bos taurus NABP1 VGNC VGNC:31859
Mus musculus NABP1 MGD MGI:1923258
Felis catus NABP1 VGNC VGNC:63706
Macaca mulatta NABP1 VGNC VGNC:75025
Others NABP1 NCBI