PURB - purine rich element binding protein B Gene

Also Known as PURBETA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5814

About PURB

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,876,299-44,885,530 (from NCBI)

This gene has 1 transcript (splice variant), 231 orthologues and 2 paralogues.

Summary

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]

PURB Products (1)

mRNA Protein Name
NM_033224.5 NP_150093.1 transcriptional activator protein Pur-beta

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PURB Protein Structure

PurA

PurA: PurA ssDNA and RNA-binding protein (31 - 279)

  • 0
  • 100
  • 200
  • 312 a.a.
Protein Preferred Names Protein Names

transcriptional activator protein Pur-beta

PURB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PURB Q96QR8 PCDHB14 Homo sapiens Q9Y5E9
Validated Y2H
32296183
Intra
PURB Q96QR8 AP1M1 Homo sapiens Q9BXS5
Validated Y2H
32296183
Intra
PURB Q96QR8 MBD2 Homo sapiens Q9UBB5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

PURB Antibodies

Cat. No. Product Name Application Reactivity
HY-P810830 PURB Antibody (YA10073) WB Human, Mouse

Related Diseases

Diseases Alias
Myelodysplastic Syndrome

  • Myelodysplastic Syndromes

  • Myelodysplasia

  • MDS

  • Myelodysplastic Syndrome Included

  • Myelodysplastic Syndrome, Susceptibility To, Included

  • Myelodysplastic Syndrome, Somatic

  • Myelodysplastic Syndrome, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11465 PURB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21412 Purb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27931 Purb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PURB MGD MGI:1338779
Felis catus PURB VGNC VGNC:80667
Macaca mulatta PURB VGNC VGNC:81749
Rattus norvegicus PURB RGD RGD:1559465
Bos taurus PURB VGNC VGNC:33573
Others PURB NCBI