PURB Antibody (YA10073)
(Synonyms: Transcriptional regulator protein Pur-beta, Purine-rich element-binding protein B, PURB)PURB Antibody (YA10073) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to PURB.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000-4000 |
Product Details
PURB Antibody (YA10073) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to PURB.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 37 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 33 kDa
Purified recombinant protein of human PURB.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PURB is a Transcriptional regulator which can act as an activator or a repressor. Represses the transcription of ACTA2 in fibroblasts and smooth muscle cells via its ability to interact with the purine-rich strand of a MCAT- containing element in the 5' flanking region of the gene. Represses the transcription of MYOCD, capable of repressing all isoforms of MYOCD but the magnitude of the repressive effects is most notable for the SMC- specific isoforms. Promotes hepatic glucose production by activating the transcription of ADCY6, leading to cAMP accumulation, increased PKA activity, CREB activation, and increased transcription of PCK1 and G6PC genes (By similarity). Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity)[1].
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Expressed in myocardium of heart failure patients. -
Isoforms & Post-Translational Modification
PURB has an amino acid length of 312, molecular weight is 33241 Da.
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Subunit
Homodimer, heterodimer with PURA and heterotrimer with PURA and YBX1/Y-box protein 1.
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SwissProt ID
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Synonyms
Transcriptional regulator protein Pur-beta, Purine-rich element-binding protein B, PURB
Documentation
References
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