QKI - QKI, KH domain containing RNA binding Gene

Homo sapiens

Also known as QK; Hqk; QK1; QK3; hqkI

Gene ID: 9444 | Gene type: protein coding

About QKI

Cytogenetic location: 6q26 Genomic coordinates (GRCh38): 6:163,414,718-163,578,592 (from NCBI)

This gene has 17 transcripts (splice variants), 257 orthologues, 4 paralogues and is associated with 71 phenotypes. Broad expression in brain (RPKM 50.5), fat (RPKM 18.4) and 21 other tissues.

Summary

The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

QKI Products(5)

mRNA	Protein	Name
NM_001301085.2	NP_001288014.1	protein quaking isoform 5
NM_006775.3	NP_006766.1	protein quaking isoform 1
NM_206853.3	NP_996735.1	protein quaking isoform 2
NM_206854.3	NP_996736.1	protein quaking isoform 3
NM_206855.3	NP_996737.1	protein quaking isoform 4

QKI Protein Structure

KH_1

0
100
200
300
341 a.a.

Protein Preferred Names

Protein Names

protein quaking

QKI/LOC100132735 fusion

Related Diseases

Diseases

Alias

Angiocentric Glioma

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Pilomyxoid Astrocytoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11500	QKI Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	QKI	VGNC	VGNC:99431
Canis familiaris	QKI	VGNC	VGNC:45232
Felis catus	QKI	VGNC	VGNC:64456
Rattus norvegicus	QKI	RGD	RGD:1584886
Mus musculus	QKI	MGD	MGI:97837
Bos taurus	QKI	VGNC	VGNC:33597