country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

QKI - QKI, KH domain containing RNA binding Gene

Also Known as QK; Hqk; QK1; QK3; hqkI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9444

About QKI

Cytogenetic location: 6q26 Genomic coordinates (GRCh38): 6:163,414,718-163,578,592 (from NCBI)

This gene has 17 transcripts (splice variants), 257 orthologues, 4 paralogues and is associated with 71 phenotypes. Broad expression in brain (RPKM 50.5), fat (RPKM 18.4) and 21 other tissues.

Summary

The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

QKI Products (5)

mRNA	Protein	Name
NM_001301085.2	NP_001288014.1	protein quaking isoform 5
NM_006775.3	NP_006766.1	protein quaking isoform 1
NM_206853.3	NP_996735.1	protein quaking isoform 2
NM_206854.3	NP_996736.1	protein quaking isoform 3
NM_206855.3	NP_996737.1	protein quaking isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables internal N(7)-methylguanine-containing RNA reader activity	IDA IDA: Inferred from direct assay	37379838	GOA
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	22398723	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	25768908	GOA
enables miRNA binding	IDA IDA: Inferred from direct assay	31792053	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in intracellular mRNA localization	IDA IDA: Inferred from direct assay	37379838	GOA
involved in mRNA stabilization	IDA IDA: Inferred from direct assay	32732889	GOA
involved in mRNA transport	IDA IDA: Inferred from direct assay	37379838	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	32732889	GOA
involved in negative regulation of macrophage differentiation	IDA IDA: Inferred from direct assay	22398723	GOA
involved in negative regulation of miRNA catabolic process	IDA IDA: Inferred from direct assay	31792053	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	31829086	GOA
involved in negative regulation of type I interferon production	IDA IDA: Inferred from direct assay	31829086	GOA
involved in regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	25768908	GOA
involved in regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	27029405	GOA
involved in regulation of macrophage differentiation	IDA IDA: Inferred from direct assay	27029405	GOA
involved in spliceosome-depend formation of circular RNA	IDA IDA: Inferred from direct assay	25768908	GOA
involved in vascular associated smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	31331967	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	37379838	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	37379838	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	37379838	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

QKI Protein Structure

KH_1

0
100
200
300
341 a.a.

Protein Preferred Names	Protein Names
protein quaking	QKI/LOC100132735 fusion

QKI Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	QKI	Q96PU8	MALT1	Homo sapiens	Q9UDY8	Anti Bait CoIP	31774199
Intra	QKI	Q96PU8	CARM1	Homo sapiens	Q86X55	Anti Tag CoIP	23455924
Intra	QKI	Q96PU8	NABP1	Homo sapiens	Q96AH0	Validated Y2H	25416956
Intra	QKI	Q96PU8	NABP1	Homo sapiens	Q96AH0	Y2H Array	25416956
Intra	QKI	Q96PU8	HNRNPK	Homo sapiens	P61978	Pull Down	16713569
Intra	QKI	Q96PU8	HNRNPK	Homo sapiens	P61978	Y2H Array	25416956
Intra	QKI	Q96PU8	HNRNPK	Homo sapiens	P61978	Y2H Array	29892012
Intra	QKI	Q96PU8	PTBP1	Homo sapiens	P26599	Pull Down	16713569
Intra	QKI	Q96PU8	PTBP1	Homo sapiens	P26599	Y2H	22365833
Intra	QKI	Q96PU8	HNRNPLL	Homo sapiens	Q8WVV9	Y2H Prey Pooling	25416956
Intra	QKI	Q96PU8	HNRNPLL	Homo sapiens	Q8WVV9	Y2H Array	25416956
Intra	QKI	Q96PU8	SNRPA	Homo sapiens	P09012	Y2H Array	25416956
Intra	QKI	Q96PU8	RBPMS	Homo sapiens	Q93062	Pull Down	16713569
Intra	QKI	Q96PU8	RBPMS	Homo sapiens	Q93062	Validated Y2H	25416956
Intra	QKI	Q96PU8	RBPMS	Homo sapiens	Q93062	Y2H Array	25416956
Intra	QKI	Q96PU8	RBM11	Homo sapiens	P57052	Validated Y2H	25416956
Intra	QKI	Q96PU8	RBM11	Homo sapiens	P57052	Y2H Prey Pooling	25416956
Intra	QKI	Q96PU8	RBFOX2	Homo sapiens	O43251	Anti Tag CoIP	33961781
Intra	QKI	Q96PU8	RBFOX2	Homo sapiens	O43251	Pull Down	16713569
Intra	QKI	Q96PU8	RBFOX2	Homo sapiens	O43251	Y2H	22365833
Intra	QKI	Q96PU8	PCBP1	Homo sapiens	Q15365	Y2H	16713569
Intra	QKI	Q96PU8	FUBP3	Homo sapiens	Q96I24	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

QKI Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82043	QK1 Antibody (YA1788)	WB, IP	Human, Mouse, Rat
HY-P82043A	QK1 Antibody (YA1788)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Angiocentric Glioma
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Pilomyxoid Astrocytoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS21287	Qki Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11500	QKI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27806	Qki Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	QKI	VGNC	VGNC:99431
Canis familiaris	QKI	VGNC	VGNC:45232
Felis catus	QKI	VGNC	VGNC:64456
Rattus norvegicus	QKI	RGD	RGD:1584886
Mus musculus	QKI	MGD	MGI:97837
Bos taurus	QKI	VGNC	VGNC:33597
Others	QKI	NCBI