FUBP3 - far upstream element binding protein 3 Gene

Also Known as FBP3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8939

About FUBP3

Cytogenetic location: 9q34.11-q34.12 Genomic coordinates (GRCh38): 9:130,579,577-130,638,352 (from NCBI)

This gene has 8 transcripts (splice variants), 276 orthologues and 12 paralogues. Ubiquitous expression in thyroid (RPKM 15.5), brain (RPKM 11.3) and 25 other tissues.

Summary

Enables single-stranded DNA binding activity. Involved in positive regulation of gene expression; positive regulation of transcription, DNA-templated; and transcription, DNA-templated. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

FUBP3 Products (1)

mRNA	Protein	Name
NM_003934.2	NP_003925.1	far upstream element-binding protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	8940189	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA-templated transcription	IDA IDA: Inferred from direct assay	8940189	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8940189	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	19087307	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8940183	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8940189	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19087307	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19087307	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FUBP3 Protein Structure

KH_1

0
100
200
300
400
500
572 a.a.

Protein Preferred Names	Protein Names
far upstream element-binding protein 3	FUSE-binding protein 3

FUBP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FUBP3	Q96I24	QKI	Homo sapiens	Q96PU8	Y2H Array	25416956
Intra	FUBP3	Q96I24	QKI	Homo sapiens	Q96PU8	Y2H Array	16713569
Intra	FUBP3	Q96I24	QKI	Homo sapiens	Q96PU8	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Calvarial Doughnut Lesions With Bone Fragility	Calvarial Doughnut Lesions With Bone Fragility With Or Without Spondylometaphyseal Dysplasia Calvarial Doughnut Lesions-Bone Fragility Syndrome CDL Doughnut Lesions Of Skull, Familial Calvarial Doughnut Lesions With Bone Fragility And Spondylometaphyseal Dysplasia Familial Doughnut Lesions Of Skull CDLSMD

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05142	FUBP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22519	Fubp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29040	Fubp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FUBP3	RGD	RGD:1307004
Felis catus	FUBP3	VGNC	VGNC:102930
Bos taurus	FUBP3	VGNC	VGNC:59216
Mus musculus	FUBP3	MGD	MGI:2443699
Canis familiaris	FUBP3	VGNC	VGNC:55565
Macaca mulatta	FUBP3	VGNC	VGNC:103266